| Short-term carnitine supplementation does not augment LCPomega3 status of vegans and lacto-ovo-vegetarians. | |
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MedLine Citation:
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PMID: 15670986 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Long-chain polyunsaturated omega-3 fatty acids (LCPomega3) synthesis, notably that of docosahexaenoic acid (DHA), from the precursor alpha-linolenic acid (ALA) proceeds with difficulty. We investigated whether carnitine supplementation augments the LCPomega3 status of apparently healthy vegans and lacto-ovo-vegetarians, who are expected to have low carnitine status. METHODS: Group A (n = 11) took 990 mg/day l-carnitine from weeks 1-4, and 990 mg/day l-carnitine + 4 mL/day linseed oil from weeks 5-8. Group B (n = 9) took 4 mL/day linseed oil from weeks 1-4, and 4 mL/day linseed oil + 990 mg/day l-carnitine from weeks 5-8. Fatty acid compositions of red blood cells, platelets, plasma cholesterol esters and plasma triglycerides were measured in the fasting state at baseline, and after 4 and 8 weeks. RESULTS: Carnitine supplementation increased plasma free and total carnitine concentrations with 30 and 25%, respectively, but did not affect eicosapentaenoic acid (EPA) and DHA contents of any of the investigated compartments. EPA and DHA changes were negatively related to initial carnitine status. CONCLUSIONS: Our results suggest that carnitine is not an important limiting factor, if any, for LCPomega3 synthesis in vegans and lacto-ovo-vegetarians. This conclusion is also likely to apply to omnivores. The most efficient means to augment EPA and particularly DHA status remains consumption of LCPomega3 from e.g. fish or supplements. |
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Authors:
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M Rebecca Fokkema; H M van Rieke; O J Bauermann; E N Smit; F A J Muskiet |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Journal of the American College of Nutrition Volume: 24 ISSN: 0731-5724 ISO Abbreviation: J Am Coll Nutr Publication Date: 2005 Feb |
Date Detail:
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Created Date: 2005-01-26 Completed Date: 2005-05-05 Revised Date: 2008-06-23 |
Medline Journal Info:
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Nlm Unique ID: 8215879 Medline TA: J Am Coll Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 58-64 Citation Subset: IM |
Affiliation:
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Department of Pathology and Laboratory Medicine, University Hospital Groningen, CMC-V, room Y1.165, PO Box 30.001, NL-9700 RB Groningen, THE NETHERLANDS. m.r.fokkema@path.azg.nl |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Platelets / metabolism Carnitine / administration & dosage*, blood* Cholesterol Esters / blood Diet, Vegetarian* Dietary Supplements Docosahexaenoic Acids / metabolism Dose-Response Relationship, Drug Eicosapentaenoic Acid / metabolism Erythrocytes / metabolism Fatty Acids, Omega-3 / metabolism* Female Humans Linseed Oil Male Triglycerides / blood alpha-Linolenic Acid / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol Esters; 0/Fatty Acids, Omega-3; 0/Triglycerides; 1553-41-9/Eicosapentaenoic Acid; 25167-62-8/Docosahexaenoic Acids; 463-40-1/alpha-Linolenic Acid; 541-15-1/Carnitine; 8001-26-1/Linseed Oil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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