| Short-term bisphosphonate therapy could ameliorate osteonecrosis: a complication in childhood hematologic malignancies. | |
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MedLine Citation:
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PMID: 20589085 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Osteonecrosis (ON) is a critical complication in the treatment of childhood leukemia and lymphoma. It particularly affects survivors of acute lymphoblastic leukemia and non-Hodgkin lymphoma reflecting the cumulative exposure to glucocorticosteroid therapy. ON is often multiarticular and bilateral, specially affecting weight-bearing joints. A conventional approach suggests a surgical intervention even if pharmacological options have also recently been investigated. We reported two cases of long time steroid-treated patients who underwent Bone Marrow Transplantation (BMT) for hematological disease. Both patients developed femoral head osteonecrosis (ON) that was diagnosed by magnetic resonance imaging (MRI) and the ON was also accompanied with pain and a limp. Despite of the conventional strategies of therapy, we successfully started a short-term treatment with bisphosphonates in order to decrease the pain and the risk of fracture. |
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Authors:
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N A Greggio; M Pillon; E Varotto; A Zanin; E Talenti; A C Palozzo; E Calore; C Messina |
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Publication Detail:
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Type: Journal Article Date: 2010-06-10 |
Journal Detail:
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Title: Case reports in medicine Volume: 2010 ISSN: 1687-9635 ISO Abbreviation: Case Report Med Publication Date: 2010 |
Date Detail:
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Created Date: 2010-06-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101512910 Medline TA: Case Report Med Country: United States |
Other Details:
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Languages: eng Pagination: 206132 Citation Subset: - |
Affiliation:
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Pediatric Endocrinology and Adolescence, Department of Pediatrics, Hospital-University of Padova, 35128 Padova, Italy. |
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