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Short-term antihypertensive therapy lowers the C-reactive protein level.
MedLine Citation:
PMID:  22371409     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Introduction: There is a growing body of data concerning significant interactions between markers of inflammation and cardiovascular diseases such as hypertension accompanied by elevated levels of plasma C-reactive protein (CRP). Therefore CRP is thought to be an independent risk factor of cardiovascular diseases. Material/Methods: The aim of this study was to evaluate the effects of antihypertensive therapy (perindopril, bisoprolol and combined therapy) on plasma CRP concentration in 67 subjects with mild or moderate hypertension who have been treatment-naive and otherwise healthy. Results: The results show a correlation between CRP level and blood pressure values. BP reduction was associated with a decrease in CRP concentration. The CRP-lowering effect of perindopril and bisoprolol was comparable and the degree of reduction might reflect their similar influence on blood pressure. Combined treatment influenced the CRP level to a greater extent than both monotherapies. Conclusions: Plasma CRP level was lowered by antihypertensive therapy independently of the drug applied. The CRP level did not normalize completely in moderate hypertensive patients.
Authors:
Andrzej Madej; Aleksandra Bołdys; Lukasz Bułdak; Krzysztof Labuzek; Marcin Basiak; Bogusław Okopień
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Publication Detail:
Type:  Journal Article     Date:  2012-02-10
Journal Detail:
Title:  Postȩpy higieny i medycyny doświadczalnej (Online)     Volume:  66     ISSN:  1732-2693     ISO Abbreviation:  Postepy Hig Med Dosw (Online)     Publication Date:  2012  
Date Detail:
Created Date:  2012-02-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101206517     Medline TA:  Postepy Hig Med Dosw (Online)     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  78-84     Citation Subset:  IM    
Affiliation:
Health Care Department, Chair of Women's Health, Medical University of Silesia, Katowice, Poland.
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