| Short-term adaptation of postprandial lipoprotein secretion and intestinal gene expression to a high-fat diet. | |
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MedLine Citation:
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PMID: 19196952 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Western diet is characterized by a hypercaloric and hyperlipidic intake, enriched in saturated fats, that is associated with the increased occurrence of metabolic diseases. To cope with this overload of dietary lipids, the intestine, which delivers dietary lipids to the body, has to adapt its capacity in lipid absorption and lipoprotein synthesis. We have studied the early effects of a high-fat diet (HFD) on intestinal lipid metabolism in mice. After 7 days of HFD, mice displayed normal fasting triglyceridemia but postprandial hypertriglyceridemia. HFD induced a decreased number of secreted chylomicrons with increased associated triglycerides. Secretion of larger chylomicrons was correlated with increased intestinal microsomal triglyceride transfer protein (MTP) content and activity. Seven days of HFD induced a repression of genes involved in fatty acid synthesis (FAS, ACC) and an increased expression of genes involved in lipoprotein assembly (apoB, MTP, and apoA-IV), suggesting a coordinated control of intestinal lipid metabolism to manage a high-fat loading. Of note, the mature form of the transcription factor SREBP-1c was increased and translocated to the nucleus, suggesting that it could be involved in the coordinated control of gene transcription. Activation of SREBP-1c was partly independent of LXR. Moreover, HFD induced hepatic insulin resistance whereas intestine remained insulin sensitive. Altogether, these results demonstrate that a short-term HFD is sufficient to impact intestinal lipid metabolism, which might participate in the development of dyslipidemia and metabolic diseases. |
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Authors:
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Sandra Jimena Hernández Vallejo; Malik Alqub; Serge Luquet; Céline Cruciani-Guglielmacci; Philippe Delerive; Jean-Marc Lobaccaro; Athina-Despina Kalopissis; Jean Chambaz; Monique Rousset; Jean-Marc Lacorte |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-02-05 |
Journal Detail:
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Title: American journal of physiology. Gastrointestinal and liver physiology Volume: 296 ISSN: 0193-1857 ISO Abbreviation: Am. J. Physiol. Gastrointest. Liver Physiol. Publication Date: 2009 Apr |
Date Detail:
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Created Date: 2009-03-31 Completed Date: 2009-06-17 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 100901227 Medline TA: Am J Physiol Gastrointest Liver Physiol Country: United States |
Other Details:
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Languages: eng Pagination: G782-92 Citation Subset: IM |
Affiliation:
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Université Pierre et Marie Curie-Paris 6, UMR S 872, INSERM, U 872, Paris, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adaptation, Physiological Animals DNA-Binding Proteins / genetics, metabolism Dietary Fats / administration & dosage*, pharmacology* Gene Expression Regulation / drug effects* Intestines / metabolism* Lipoproteins / secretion* Male Mice Mice, Knockout Orphan Nuclear Receptors Postprandial Period / physiology* Receptors, Cytoplasmic and Nuclear / genetics, metabolism Sterol Regulatory Element Binding Protein 1 / genetics, metabolism Time Factors Weight Gain |
| Grant Support | |
ID/Acronym/Agency:
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//Howard Hughes Medical Institute |
| Chemical | |
Reg. No./Substance:
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0/DNA-Binding Proteins; 0/Dietary Fats; 0/Lipoproteins; 0/Orphan Nuclear Receptors; 0/Receptors, Cytoplasmic and Nuclear; 0/Srebf1 protein, mouse; 0/Sterol Regulatory Element Binding Protein 1; 0/liver X receptor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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