| Short-term therapy with celecoxib and lansoprazole modulates Th1/ Th2 immune response in human gastric mucosa. | |
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MedLine Citation:
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PMID: 21083751 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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BACKGROUND: Selective cyclooxygenase-2 (COX-2) inhibitors and proton pump inhibitors may exert immune-mediated effects in human gastric mucosa. T-cell immune response plays a role in Helicobacter pylori-induced pathogenesis. This study evaluated effects of celecoxib and lansoprazole on T-helper (Th) 1 and Th2 immune response in human gastric mucosa. METHODS: Dyspeptic patients with or without osteoarticular pain were given one of the following 4-week therapies: celecoxib 200 mg, celecoxib 200 mg plus lansoprazole 30 mg, and lansoprazole 30 mg daily. Expression of COX-2, T-bet, and pSTAT6 and production of prostaglandin E₂ (PGE₂), interferon (IFN)-γ, and interleukin (IL)-4 were determined in gastric biopsies before and after therapy. Histology was evaluated. RESULTS: Cyclooxygenase-2 expression and PGE₂ production was higher, and Th1 signaling pathway was predominant in H. pylori-infected vs. uninfected patients. T-bet expression and IFN-γ production increased, while STAT6 activation and IL-4 production decreased following therapy with celecoxib and celecoxib plus lansoprazole, respectively. Th1 and Th2 signaling pathways down-regulated after therapy with lansoprazole, and this was associated with an improvement of gastritis. Effect of therapy was not affected by H. pylori status. CONCLUSION: Celecoxib and lansoprazole modulate Th1/Th2 immune response in human gastric mucosa. The use of these drugs may interfere with long-term course of gastritis. |
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Authors:
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Tiziana Larussa; Evelina Suraci; Isabella Leone; Immacolata Nazionale; Ludovico Abenavoli; Olimpio Galasso; Andrea Amorosi; Maria Imeneo; Francesco Luzza |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Helicobacter Volume: 15 ISSN: 1523-5378 ISO Abbreviation: Helicobacter Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-11-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9605411 Medline TA: Helicobacter Country: United States |
Other Details:
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Languages: eng Pagination: 449-59 Citation Subset: IM |
Copyright Information:
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© 2010 Blackwell Publishing Ltd. |
Affiliation:
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Dipartimento di Medicina Sperimentale e Clinica Dipartimento di Scienze Mediche, Università di Catanzaro "Magna Graecia", Catanzaro, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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