| Short-term Inhalation of Sevoflurane during Induction of General Anesthesia Can Inhibit the A-line ARX Index Response to Intubation: A Randomized Trial. | |
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MedLine Citation:
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PMID: 22196062 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Background: Monitoring hypnotic depth is used to prevent awareness during general anesthesia. We used the A-line ARX index (AAI) to assess the effect of shortterm inhalation of sevoflurane in the prevention of intubation-induced inadequate hypnotic depth during anesthetic induction. Methods: Thirty patients were randomly divided into the sevoflurane and non-sevoflurane groups, both of which were given 3 μg kg-1 fentanyl, 4 mg kg-1 thiamylal, and 0.2 mg kg-1 cis-atracurium intravenously to induce general anesthesia. The sevoflurane group then inhaled 6% sevoflurane and 4 L/min O2 for 3 minutes, whereas the non-sevoflurane group was given 4 L/min O2 alone. Both groups were intubated 3 minutes after induction. Measurements of the AAI, non-invasive blood pressure, and heart rate were performed every minute, starting 3 minutes prior to induction until 9 minutes after intubation. Results: Intubation induced a significant AAI elevation in the non-sevoflurane group (47.13 ± 20.88, 48.13 ± 20.05, 40.87 ± 15.86 and 31.27 ± 15.26 at 1, 2, 3 and 4 minutes after intubation, respectively, vs. 17.67 ± 6.44 at 3 minutes after induction; p < 0.05), whereas the AAI remained unchanged for the sevoflurane group following intubation. Moreover, the non-sevoflurane group demonstrated higher AAI values after intubation compared with the sevoflurane group. There were no significant differences in blood pressure and heart rate between the two groups throughout the study. Conclusion: Adding 6% sevoflurane with 4 L/min O2 for 3 minutes during the induction period prevented inadequate hypnotic depth caused by intubation but was not sufficient to inhibit fluctuations in hemodynamics. |
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Authors:
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Ching-Feng Lin; Ching-Yue Yang; Edison Chao; Mel S Lee; Lai-Chu See |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Chang Gung medical journal Volume: 34 ISSN: 2072-0939 ISO Abbreviation: Chang Gung Med J Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-12-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101088034 Medline TA: Chang Gung Med J Country: China (Republic : 1949- ) |
Other Details:
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Languages: eng Pagination: 599-606 Citation Subset: IM |
Affiliation:
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Department of Anesthesiology, Chang Gung Memorial Hospital at Linkou, Chang Gung University College of Medicine, Taoyuan, Taiwan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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