Document Detail


Short-term exercise training prevents micro- and macrovascular disease following coronary stenting.
MedLine Citation:
PMID:  20299615     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of this study was to determine the effects of exercise on coronary blood flow and macrovascular atherosclerosis in response to stent deployment. Male Yucatan swine were placed on a control diet (C); on a high-fat/cholesterol diet (hypercholesterolemic; H); or on a high-fat/cholesterol diet and aerobically exercise trained (HX) starting after 36 wk on the diet. All pigs underwent coronary angiography and intravascular ultrasound (IVUS) guided placement of a bare metal stent in the circumflex coronary artery after 40 wk on diets and 3 wk later pigs underwent repeat angiography and IVUS and coronary blood flow (CBF) measurement. Average peak velocity (APV) was measured under basal conditions and in response to intracoronary application of the endothelium-independent vasodilator adenosine and the endothelium-dependent vasodilator bradykinin. There was a similar approximately 8-fold increase in total cholesterol in H and HX compared with control. Baseline CBF was increased above control and H in HX (P<0.05). At all doses adenosine-induced CBF was impaired in H, but preserved in HX. Similarly, bradykinin-induced CBF was impaired in H vs. control, yet was potentiated in HX. Microvessel density was decreased in H and preserved in HX vs. control. Native atheroma in HX was lower relative to H and control, while in-stent stenosis in HX was not different from H. Hyperlipidemia-induced microvascular dysfunction after stent deployment may be a result of reduction in microvessel density. This is the first report that short-term exercise training near the time of stenting prevents stent-induced microvascular dysfunction and attenuates native atheroma independent of changes in plasma cholesterol in this porcine model.
Authors:
Xin Long; Ian N Bratz; Mouhamad Alloosh; Jason M Edwards; Michael Sturek
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-03-18
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  108     ISSN:  1522-1601     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-03     Completed Date:  2010-10-08     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1766-74     Citation Subset:  IM    
Affiliation:
Department of Cellular and Integrative Physiology, Indiana University School of Medicine, 635 Barnhill Dr., MS 385, Indianapolis, IN 46202-5120, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Vessel Prosthesis / adverse effects*
Coronary Artery Disease / etiology,  physiopathology*,  prevention & control*,  surgery
Exercise Therapy / methods*
Male
Microvessels / physiopathology*
Physical Exertion*
Stents / adverse effects*
Swine
Grant Support
ID/Acronym/Agency:
HL-052490/HL/NHLBI NIH HHS; HL-062552/HL/NHLBI NIH HHS; RR-013223/RR/NCRR NIH HHS; T32-AR-048523/AR/NIAMS NIH HHS; T32-HL-007094/HL/NHLBI NIH HHS
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