| Short-term Effects of Humidification Devices on Respiratory Pattern and Arterial Blood Gases During Noninvasive Ventilation. | |
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MedLine Citation:
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PMID: 22417382 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: The impact of the humidification devices on ventilatory and arterial blood gases parameters during noninvasive ventilation (NIV) remains controversial. The aim of the study was to compare the short term impact of heat and moisture exchangers (HME) and heated humidifiers (HH) during NIV for either hypercapnic or hypoxemic acute respiratory failure. METHODS: Consecutive patients receiving NIV were successively treated with HME and HH in randomized order for 30 minutes each. At the end of each period, arterial blood gases were measured and ventilatory parameters were recorded. RESULTS: Eighty-one patients were enrolled, of which 52 were hypercapnic (with or without acidosis) and 29 hypoxemic. Minute-ventilation was greater with the HME in comparison with the HH (15.5 ± 6.4 vs. 13.7 ± 5.8 l/min, P<0.001), while PaCO₂ was increased when using HME, indicating a dead space effect. This effect was observed in all patients, but was more pronounced in hypercapnic patients (PaCO₂ 63 ± 18 mmHg with HME vs. 57 ± 14 with HH, P<0.001). In a subgroup of 19 patients with respiratory acidosis, alveolar hypoventilation improved only with the HH. The amplitude of the dead space impact was a function of the degree of hypercapnia. CONCLUSION: Use of an HME decreased CO₂ elimination during noninvasive ventilation despite increased minute ventilation, especially in hypercapnic patients. |
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Authors:
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François Lellouche; Claudia Pignataro; Salvatore Maurizio Maggiore; Emmanuelle Girou; Nicolas Deye; Solenne Taillé; Marc Fischler; Laurent Brochard |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-3-13 |
Journal Detail:
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Title: Respiratory care Volume: - ISSN: 0020-1324 ISO Abbreviation: - Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-3-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7510357 Medline TA: Respir Care Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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