| The short-term effect of neoadjuvant chemoradiation on anorectal function in low and midrectal cancer: analysis using preoperative manometric data. | |
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MedLine Citation:
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PMID: 20305445 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: The purpose of this study was to evaluate the short-term preoperative effects of neoadjuvant chemoradiation on anorectal function, excluding the bias of postoperative impairment. METHODS: We analyzed 80 patients on whom preoperative anorectal manometry data were available for both prechemoradiation and postchemoradiation. Patients were divided into 2 groups according to the tumor location; lower rectum (n = 52) and mid rectum (n = 28). The paired t test was used to compare prechemoradiation and postchemoradiation parameters including the mean resting pressure, maximum squeeze pressure, percentage asymmetry of the resting and squeeze sphincter, length of the high-pressure zone, rectal sensory threshold, and rectal compliance. RESULTS: In patients with a lower rectal cancer, there were significant differences in the percentage asymmetry of the squeeze sphincter (27.81 +/- 6.46 vs 25.38 +/- 5.93%, P < .01), length of the high-pressure zone (2.14 +/- 0.74 vs 2.33 +/- 0.72 cm, P = .05), and rectal compliance (1.14 +/- 0.41 vs 1.02 +/- 0.40 mL/mmHg, P = .04). In patients with midrectal cancer, only the mean resting pressure increased significantly (45.08 +/- 18.57 vs 52.83 +/- 17.87 mmHg, P < .01). Clinical symptom evaluation demonstrated a significant decrease in the number of defecations and the frequency of tenesmus. CONCLUSION: Neoadjuvant chemoradiation did not impair overall short-term sphincter function significantly, regardless of the location of the primary tumor. Although there was a decrease in rectal compliance, it seemed that the tumor-downsizing effect compensated the expected worsening of anorectal function in the early postchemoradiation period. |
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Authors:
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Na Young Jang; Tae Jin Han; Sung-Bum Kang; Duck-Woo Kim; In Ah Kim; Jae-Sung Kim |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Diseases of the colon and rectum Volume: 53 ISSN: 1530-0358 ISO Abbreviation: Dis. Colon Rectum Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-03-22 Completed Date: 2010-05-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372764 Medline TA: Dis Colon Rectum Country: United States |
Other Details:
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Languages: eng Pagination: 445-9 Citation Subset: IM |
Affiliation:
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Department of Radiation Oncology, Seoul National University Bundang Hospital, Bundang-gu, Gyeonggi-do, Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma
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drug therapy*,
pathology,
physiopathology*,
radiotherapy* Adult Aged Antineoplastic Combined Chemotherapy Protocols / therapeutic use Chi-Square Distribution Female Humans Male Manometry Middle Aged Neoadjuvant Therapy Neoplasm Staging Rectal Neoplasms / drug therapy*, pathology, physiopathology*, radiotherapy* Retrospective Studies Treatment Outcome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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