Document Detail

Short-term aerobic exercise reduces nitroglycerin-induced orthostatic intolerance in older adults with type 2 diabetes.
MedLine Citation:
PMID:  21346593     Owner:  NLM     Status:  MEDLINE    
AIMS/HYPOTHESIS: Older adults are at a high risk for syncope due to orthostatic intolerance (OI), and this risk increases with comorbid type 2 diabetes and vasoactive medications. Despite many benefits, previous investigations have shown worsening OI with aerobic training. We examined whether aerobic exercise reduced OI in older adults with type 2 diabetes who were given a short-acting vasoactive agent (nitroglycerin).
METHODS: Forty older adults (25 males and 15 females, mean age 71.4 ± 0.7 years, ranging in age from 65 to 83 years) with type 2 diabetes were recruited. Subjects were randomized to each of 2 groups: an aerobic group (3 months of vigorous aerobic exercise) and a nonaerobic (no aerobic exercise) group. Exercise sessions were supervised by a certified exercise trainer 3 times per week. After being given 400 μg of sublingual nitroglycerin, each subject was placed in a 70° head-up tilt for 30 minutes.
RESULTS: When the 2 groups were compared using a Cox proportional hazards model, tilt table tolerance was significantly better in the aerobic group as compared to in the nonaerobic group (χ(2)(MC) = 7.271, P = 0.007).
CONCLUSIONS: Our findings indicate that a relatively short aerobic exercise intervention can improve postnitroglycerin orthostatic tolerance in older adults with type 2 diabetes.
Kenneth M Madden; Chris K Lockhart; Tiffany F Potter; Darcye J Cuff; Graydon S Meneilly
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  57     ISSN:  1533-4023     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-06-02     Completed Date:  2011-09-27     Revised Date:  2014-03-03    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  666-71     Citation Subset:  IM    
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MeSH Terms
Accidental Falls / prevention & control
Aged, 80 and over
Body Mass Index
Diabetes Mellitus, Type 2 / complications,  therapy*
Nitroglycerin / diagnostic use*
Orthostatic Intolerance / chemically induced,  complications,  diagnosis,  prevention & control*
Physical Fitness
Proportional Hazards Models
Single-Blind Method
Vasodilator Agents / diagnostic use*
Grant Support
77789-2//Canadian Institutes of Health Research; //Canadian Institutes of Health Research
Reg. No./Substance:
0/Vasodilator Agents; G59M7S0WS3/Nitroglycerin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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