| Short-term Aerobic Exercise Reduces Nitroglycerin-Induced Orthostatic Intolerance in Older Adults with Type 2 Diabetes. | |
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MedLine Citation:
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PMID: 21346593 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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AIMS/HYPOTHESIS:: Older adults are at high risk for syncope due to orthostatic intolerance (OI), and this risk increases with co-morbid Type 2 diabetes and vasoactive medications. Despite many benefits, previous investigations have shown worsening OI with aerobic training. We examined whether aerobic exercise reduced OI in older adults with Type 2 diabetes that were given a short-acting vasoactive agent (nitroglycerin, GTN). METHODS:: Forty older adults (25 males and 15 females, mean age 71.4±0.7, ranging in age from 65 to 83) with Type 2 diabetes were recruited. Subjects were randomized to each of 2 groups: an aerobic group (AT, 3 months vigorous aerobic exercise), and a nonaerobic (NA, no aerobic exercise) group. Exercise sessions were supervised by a certified exercise trainer 3 times per week. After being given 400 micrograms of sublingual nitroglycerin, each subject was placed in a 70 degree head-up tilt for 30 minutes. RESULTS:: When the two groups were compared using a Cox proportional hazards model, tilt table tolerance (TTT) was significantly better in the AT group as compared to the NA group (χMC=7.271, p=0.007). CONCLUSIONS:: Our findings indicate that a relatively short aerobic exercise intervention can improve post-GTN orthostatic tolerance in older adults with Type 2 diabetes. |
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Authors:
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Kenneth M Madden; Chris Lockhart; Tiffany F Potter; Darcye Cuff; Graydon S Meneilly |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-2-21 |
Journal Detail:
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Title: Journal of cardiovascular pharmacology Volume: - ISSN: 1533-4023 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-2-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7902492 Medline TA: J Cardiovasc Pharmacol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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VITALiTY (Vancouver Initiative to Add Life to Years) Research Laboratory, Division of Geriatric Medicine, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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