Document Detail

Short-term ACE inhibition has no effect on sodium and water excretion during PEEP ventilation.
MedLine Citation:
PMID:  9466091     Owner:  NLM     Status:  MEDLINE    
The short-term effect of intravenous (i.v.) angiotensin converting enzyme (ACE) inhibitor enalaprilat in 10 critically ill patients, being ventilated with positive end-expiratory pressure (PEEP), on sodium and water excretion was investigated. Mean arterial pressure (MAP) decreased. Heart rate and central venous pressure (CVP) did not change. Glomerular filtration rate (GFR), urine volume (V) and sodium excretion (UNaV) decreased in two patients with reduced MAP. GFR, V and UNaV increased in two patients with decreased MAP. No relation between changes in MAP and excretion was observed in six patients. ACE decreased in all patients. Plasma renin activity increased, aldosterone decreased, while atrial natriuretic peptide as well as antidiuretic hormone did not change. Enalaprilat did not facilitate sodium and water excretion during ventilation with PEEP. Decreased MAP indicates that the investigated patients were very dependent on their renin-angiotensin system to maintain systemic perfusion pressure. Base-line MAP and CVP values were no predictors of haemodynamic and excretory changes following acute ACE inhibition.
M Wenz; N Eckelt; F Rissel; G Kaczmarczyk
Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of anaesthesiology     Volume:  14     ISSN:  0265-0215     ISO Abbreviation:  Eur J Anaesthesiol     Publication Date:  1997 Nov 
Date Detail:
Created Date:  1998-03-26     Completed Date:  1998-03-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8411711     Medline TA:  Eur J Anaesthesiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  566-75     Citation Subset:  IM    
AG Experimental Anaesthesia, Department of Anaesthesiology and Operative Intensive Care Medicine, Virchow-Klinikum, Humboldt-Universität zu Berlin, Germany.
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MeSH Terms
Angiotensin-Converting Enzyme Inhibitors / administration & dosage,  pharmacology*
Blood Pressure / drug effects,  physiology
Enalaprilat / administration & dosage,  pharmacology*
Glomerular Filtration Rate
Heart Rate / drug effects,  physiology
Injections, Intravenous
Middle Aged
Positive-Pressure Respiration*
Sodium / urine*
Water / metabolism*
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 7440-23-5/Sodium; 7732-18-5/Water; 84680-54-6/Enalaprilat
Comment In:
Eur J Anaesthesiol. 1998 Nov;15(6):807-8   [PMID:  9884879 ]

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