| Short telomeres may play a role in placental dysfunction in preeclampsia and intrauterine growth restriction. | |
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MedLine Citation:
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PMID: 20350645 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Telomeres shorten and aggregate with cellular senescence and oxidative stress. Telomerase and its catalytic component human telomerase reverse-transcriptase regulate telomere length. The pathogenesis of preeclampsia and intrauterine growth restriction involves hypoxic stress. We aimed to assess telomere length in trophoblasts from pregnancies with those complications. STUDY DESIGN: Placental specimens from 4 groups of patients were studied: severe preeclampsia, intrauterine growth restriction, preeclampsia combined with intrauterine growth restriction, and uncomplicated (control). Telomere length and human telomerase reverse-transcriptase expression were assessed by using quantitative fluorescence-in-situ protocol and immunohistochemistry. RESULTS: Telomere length was significantly lower in preeclampsia, intrauterine growth restriction, and preeclampsia plus intrauterine growth restriction placentas. More aggregates were found in preeclampsia, but not in intrauterine growth restriction placentas. Human telomerase reverse-transcriptase was significantly higher in the controls compared with the other groups. CONCLUSION: Telomeres are shorter in placentas from preeclampsia and intrauterine growth restriction pregnancies. Increased telomere aggregate formation in preeclampsia but not in intrauterine growth restriction pregnancies, implies different placental stress-related mechanisms in preeclampsia with or without intrauterine growth restriction. |
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Authors:
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Tal Biron-Shental; Rivka Sukenik-Halevy; Yudith Sharon; Lilach Goldberg-Bittman; Dvora Kidron; Moshe D Fejgin; Aliza Amiel |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 202 ISSN: 1097-6868 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-03-30 Completed Date: 2010-04-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 381.e1-7 Citation Subset: AIM; IM |
Copyright Information:
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Copyright 2010 Mosby, Inc. All rights reserved. |
Affiliation:
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Department of Obstetrics and Gynecology, Meir Medical Center, Kfar Saba, Israel. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Biopsy Cell Aging / genetics* Female Fetal Growth Retardation / genetics*, metabolism, pathology Humans Immunohistochemistry In Situ Hybridization, Fluorescence Oxidative Stress Placenta / pathology, physiopathology Placenta Diseases / genetics*, metabolism, pathology Pre-Eclampsia / genetics*, metabolism, pathology Pregnancy Pregnancy Trimester, Third Telomerase / genetics, metabolism Telomere / metabolism, pathology* |
| Chemical | |
Reg. No./Substance:
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EC 2.7.7.49/Telomerase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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