| Short-tau inversion-recovery (STIR) sequence magnetic resonance imaging evaluation of orbital structures in Graves' orbitopathy. | |
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MedLine Citation:
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PMID: 22040641 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate the orbital structures and to establish correlations with disease activity and severity in patients with Graves' hyperthyroidism and orbitopathy (GO) using short-tau inversion-recovery (STIR) sequence magnetic resonance imaging (MRI). METHODS: Observational, cross-sectional, case-control study. Twenty-eight patients with euthyroid status after treatment and GO (GO group) and 15 control subjects (control group) were included. Patients underwent a complete ophthalmologic examination and were then assessed according to the EUGOGO (European Group on Graves' Orbitopathy) recommendations. Muscle cross-sectional areas, orbital tissue volumes and the signal intensity ratio (SIR) from the most inflamed extraocular muscle were calculated using a STIR-T2 weighted sequence MRI. Correlations between clinical and MRI measurements were analyzed. RESULTS: Enlargements in the cross-sectional areas and volumes were significant for most EOMs (P<.001), but not for the lateral rectus muscle cross-sectional area. A significant difference in SIR values between patients with GO and control subjects (P<.001) was found. No significant correlations were found between muscle cross-sectional areas, orbital tissue volumes, SIR values and the clinical activity parameters. CONCLUSIONS: Given the small sample size of our study, with the obvious need for larger clinical trials, we were unable to demonstrate that the STIR sequences in MRI are a sensitive tool in assessing patients with longstanding GO in order to detect inflammatory changes and activity follow-up, possibly because it is in inactive phase. Meanwhile, it is still necessary to continue performing a thorough clinical evaluation in the therapeutic management of GO. |
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Authors:
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N Rodríguez-González; C Pérez-Rico; R López-Para Giménez; J Arévalo-Serrano; B Del Amo García; L Calzada Domingo; L Flores Ruiz; R Blanco |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-9-9 |
Journal Detail:
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Title: Archivos de la Sociedad Espanola de Oftalmologia Volume: 86 ISSN: 1989-7286 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-1 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 1304603 Medline TA: Arch Soc Esp Oftalmol Country: - |
Other Details:
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Languages: ENG; SPA Pagination: 351-357 Citation Subset: - |
Copyright Information:
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Copyright © 2010 Sociedad Española de Oftalmología. Published by Elsevier Espana. All rights reserved. |
Affiliation:
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Servicio de Oftalmología, Hospital General Universitario de Guadalajara, Guadalajara. |
Vernacular Title:
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Evaluación de la órbita mediante secuencias short-tau inversion-recovery (STIR) en resonancia nuclear magnética en la orbitopatía de Graves. |
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