Document Detail


Short tandem repeat typing in exon 1 of the androgen receptor gene.
MedLine Citation:
PMID:  12935589     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Exon 1 of the androgen receptor (AR) gene on the X chromosome contains a polymorphic CAG trinucleotide short tandem repeat. We describe here the rapid and reliable method of typing CAG repeats using electrophoresis, with denaturing polyacrylamide gel and an allelic ladder marker. Twenty-one alleles (the repeat number ranges from 13 to 35) were found using CAG repeat typing in normal Japanese individuals (83 males and 82 females). The allelic diversity (h) calculated was h=0.889, illustrating that CAG repeats at the AR locus is a highly polymorphic system.
Authors:
Kenji Fujii; Tatsuyuki Okiura; Koji Nishimura; Chitoshi Orimoto; Hiroaki Nishimukai
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Legal medicine (Tokyo, Japan)     Volume:  5 Suppl 1     ISSN:  1344-6223     ISO Abbreviation:  Leg Med (Tokyo)     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-08-25     Completed Date:  2003-12-03     Revised Date:  2004-11-18    
Medline Journal Info:
Nlm Unique ID:  100889186     Medline TA:  Leg Med (Tokyo)     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  S201-3     Citation Subset:  IM    
Affiliation:
Department of Legal Medicine, Ehime University School of Medicine, Ehime 791-0295, Japan. nishimuk@m.ehime-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Chromosomes, Human, X
Electrophoresis, Polyacrylamide Gel
Exons*
Female
Gene Frequency
Humans
Male
Polymerase Chain Reaction
Polymorphism, Genetic
Receptors, Androgen / genetics*
Sequence Analysis, DNA
Tandem Repeat Sequences*
Chemical
Reg. No./Substance:
0/Receptors, Androgen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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