Document Detail


Short report: treatment of gastric ulcer with lansoprazole or ranitidine: a multicentre clinical trial.
MedLine Citation:
PMID:  8186337     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We studied the effectiveness of lansoprazole and ranitidine in promoting gastric ulcer healing in a multicentre double-blind trial, by comparing the proportion of healed ulcers after 4 and 8 weeks of treatment. One hundred and fifty-eight patients were randomly given either ranitidine (150 mg each morning and at bedtime) or lansoprazole (30 mg each morning and placebo at bedtime). One hundred and twenty-eight patients completed the trial (62 taking lansoprazole, 66 taking ranitidine). Fifty-one (80%) of those treated with lansoprazole and forty-two (62%) of those treated with ranitidine had healed ulcers at 4 weeks (P < 0.05). Sixty-one (98%) patients who received lansoprazole and 57 (86%) who received ranitidine had healed ulcers at 8 weeks (P < 0.05). The observed differences were not significant in the intention-to-treat analysis. No serious adverse event was reported with lansoprazole.
Authors:
P Michel; M Lemaire; R Colin; G Bommelaer; J C Rambaud; J L Dupas; M A Bigard; J C Verwaerd
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Alimentary pharmacology & therapeutics     Volume:  8     ISSN:  0269-2813     ISO Abbreviation:  Aliment. Pharmacol. Ther.     Publication Date:  1994 Feb 
Date Detail:
Created Date:  1994-06-23     Completed Date:  1994-06-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8707234     Medline TA:  Aliment Pharmacol Ther     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  119-22     Citation Subset:  IM    
Affiliation:
Hôpital Charles Nicolle, Rouen, France.
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MeSH Terms
Descriptor/Qualifier:
2-Pyridinylmethylsulfinylbenzimidazoles
Administration, Oral
Adult
Aged
Anti-Ulcer Agents / administration & dosage,  therapeutic use*
Double-Blind Method
Female
Humans
Male
Middle Aged
Omeprazole / administration & dosage,  analogs & derivatives*,  therapeutic use
Ranitidine / administration & dosage,  therapeutic use*
Stomach Ulcer / drug therapy*
Chemical
Reg. No./Substance:
0/2-Pyridinylmethylsulfinylbenzimidazoles; 0/Anti-Ulcer Agents; 103577-45-3/lansoprazole; 66357-35-5/Ranitidine; 73590-58-6/Omeprazole
Comments/Corrections
Erratum In:
Aliment Pharmacol Ther 1994 Jun;8(3):357

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