Document Detail


Short report: octreotide in the treatment of external pancreatic fistulas.
MedLine Citation:
PMID:  8364137     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The efficacy of the long-lasting somatostatin analogue, octreotide, in the treatment of high-output pancreatic fistulas was investigated in this prospective, open study. Sixteen patients with post-operative pancreatic fistulas were treated with subcutaneous injections of octreotide 0.1 mg b.d. The output of the fistulas before the somatostatin therapy ranged between 190 and 570 ml/day. The therapy was begun on average 17 days following the appearance of the fistula (range 4 to 35 days). The decrease in volume one day after initiation of therapy ranged from 26% to 69%. By the third day of treatment the fistula volume decreased to 0-45% of the initial output. The treatment resulted in the closure of 14 of the 16 fistulas; the time to closure ranging from 3 to 15 days. The results suggest that octreotide is a useful adjuvant agent in the treatment of an external pancreatic fistula.
Authors:
Z Tulassay; L Flautner; A Vadász; I Fehérvári
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Alimentary pharmacology & therapeutics     Volume:  7     ISSN:  0269-2813     ISO Abbreviation:  Aliment. Pharmacol. Ther.     Publication Date:  1993 Jun 
Date Detail:
Created Date:  1993-10-05     Completed Date:  1993-10-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8707234     Medline TA:  Aliment Pharmacol Ther     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  323-5     Citation Subset:  IM    
Affiliation:
Department of Medicine, Semmelweis University, Medical School, Budapest, Hungary.
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MeSH Terms
Descriptor/Qualifier:
Adult
Cholangiopancreatography, Endoscopic Retrograde
Female
Humans
Injections, Subcutaneous
Male
Middle Aged
Octreotide / administration & dosage,  adverse effects,  therapeutic use*
Pancreatic Fistula / drug therapy*,  etiology
Postoperative Complications / drug therapy*
Prospective Studies
Chemical
Reg. No./Substance:
83150-76-9/Octreotide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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