Document Detail


Short report: neonatal screening pilot study of Toxoplasma gondii congenital infection in Mexico.
MedLine Citation:
PMID:  15741549     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Congenital toxoplasmosis is an obstetric problem in Mexico, but its actual frequency is unknown. Using a network for screening of non-infectious disorders, we performed a pilot study to determine the frequency of IgM antibodies to Toxoplasma gondii in 1,003 infants (53.1% male, mean +/- SD age = 18.3 +/- 13.0 days, birth weight = 3.116 +/- 0.453 kg) in Mexico City from March to April 2003. Blood samples embedded in filter paper were assayed for IgM antibodies using a capture enzyme-linked immunosorbent assay and results were confirmed by Western blot. Two asymptomatic newborns, one of them premature, had IgM and IgG antibodies in a serum sample taken from both the infant and the mother and were clinically followed. Our data suggest a frequency of approximately two cases of congenital T. gondii infection per 1,000 newborns in Mexico City.
Authors:
Marcela Vela-Amieva; Irma Cañedo-Solares; Pedro Gutiérrez-Castrellón; Martha Pérez-Andrade; Claudia González-Contreras; Joel Ortíz-Cortés; Venancio Ortega-Velázquez; Maria de la Luz Galván-Ramírez; Matilde Ruiz-García; Patrica Saltigeral-Simentel; Juan Carlos Ordaz-Favila; Carmen Sánchez; Dolores Correa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of tropical medicine and hygiene     Volume:  72     ISSN:  0002-9637     ISO Abbreviation:  Am. J. Trop. Med. Hyg.     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2005-03-02     Completed Date:  2005-04-07     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370507     Medline TA:  Am J Trop Med Hyg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  142-4     Citation Subset:  AIM; IM    
Affiliation:
Servicio de Genética de la Nutrición, Instituto Nacional de Pediatría, Secretaría de Salud, Mexico City, Mexico. amieva@servidor.unam.mx <amieva@servidor.unam.mx>
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MeSH Terms
Descriptor/Qualifier:
Adult
Animals
Antibodies, Protozoan / blood
Blotting, Western
Enzyme-Linked Immunosorbent Assay
Female
Humans
Infant, Newborn
Infectious Disease Transmission, Vertical / prevention & control*
Male
Mexico / epidemiology
Pilot Projects
Prevalence
Risk Factors
Toxoplasma / immunology
Toxoplasmosis, Congenital / epidemiology*,  etiology,  prevention & control*,  transmission
Chemical
Reg. No./Substance:
0/Antibodies, Protozoan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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