Document Detail

Short report: interferon-alpha decreases 14C-aminopyrine breath test values in patients with chronic hepatitis C.
MedLine Citation:
PMID:  7918934     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate the effect of interferon-alpha on cytochrome P-450 dependent microsomal function. METHODS: The 14C-aminopyrine breath test was performed before, during and after a standard dose of interferon-alpha (3,000,000 units three times per week) was administered for at least six months (nine patients with chronic hepatitis C). RESULTS: Mean aminopyrine breath test values obtained during therapy were significantly lower than either pre- or post-treatment, the degree of reduction varying widely between individuals. Pre- and post-treatment aminopyrine breath test values did not differ significantly. CONCLUSION: Interferon therapy is associated with a significant and transient inhibition of cytochrome P-450 activity, which should be taken into account when prescribing concurrent therapy with drugs metabolized by this pathway.
Y Horsmans; R Brenard; A P Geubel
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Alimentary pharmacology & therapeutics     Volume:  8     ISSN:  0269-2813     ISO Abbreviation:  Aliment. Pharmacol. Ther.     Publication Date:  1994 Jun 
Date Detail:
Created Date:  1994-11-10     Completed Date:  1994-11-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8707234     Medline TA:  Aliment Pharmacol Ther     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  353-5     Citation Subset:  IM    
Department of Gastroenterology, Cliniques Universitaires St-Luc, Brussels, Belgium.
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MeSH Terms
Aminopyrine N-Demethylase / metabolism
Breath Tests
Chronic Disease
Cytochrome P-450 Enzyme System / antagonists & inhibitors,  metabolism*
Drug Administration Schedule
Hepatitis C / therapy*
Interferon-alpha / administration & dosage*
Middle Aged
Reg. No./Substance:
0/Interferon-alpha; 58-15-1/Aminopyrine; 9035-51-2/Cytochrome P-450 Enzyme System; EC 1.5.3.-/Aminopyrine N-Demethylase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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