Document Detail

Short report: effect of two prokinetic drugs on the electrical and motor activity of the small bowel in dogs.
MedLine Citation:
PMID:  8364138     Owner:  NLM     Status:  MEDLINE    
The effects of trimebutine and domperidone, on the electrical and motor activity of the upper small bowel in dogs, were studied simultaneously by means of a suction electrode and a manometric catheter. Trimebutine, given during phases I and II of the migratory motor complex, was followed by a period of regular spike potentials and contractions; the increased motor activity was significantly greater when the drug was given during phase II. Domperidone, when injected in phase I, was followed by an irregular pattern of spike potentials and contractions of low amplitude. By contrast, activity was not augmented when the drug was given during phase II. We conclude that the effects of drugs, such as trimebutine and domperidone, on the canine small bowel are influenced by the phase of the migratory motor complex.
C Defilippi; E Gomez
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Alimentary pharmacology & therapeutics     Volume:  7     ISSN:  0269-2813     ISO Abbreviation:  Aliment. Pharmacol. Ther.     Publication Date:  1993 Jun 
Date Detail:
Created Date:  1993-10-05     Completed Date:  1993-10-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8707234     Medline TA:  Aliment Pharmacol Ther     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  327-30     Citation Subset:  IM    
Department of Physiology and Biophysics, Faculty of Medicine, University of Chile, Santiago.
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MeSH Terms
Domperidone / pharmacology*
Gastrointestinal Motility / drug effects*
Membrane Potentials / drug effects
Muscle Contraction / drug effects
Myoelectric Complex, Migrating / drug effects*
Trimebutine / pharmacology*
Reg. No./Substance:
39133-31-8/Trimebutine; 57808-66-9/Domperidone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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