Document Detail


Short-range intermittent claudication and rest pain: microcirculatory effects of pentoxifylline in a randomized, controlled trial.
MedLine Citation:
PMID:  11865832     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The efficacy of pentoxifylline (PXF) in severe intermittent claudication was studied comparing PXF and placebo. Patients were randomized into two treatment plans: PXF (2400 mg, four 600-mg tablets daily) or equivalent placebo was administered for 10 days. The exercise protocol associated with treatment was conducted under supervision. Skin flux (RF) was measured at rest and after 1 minute of exercise (AEF = after exercise flux; 3 km/hr, 12% inclination) with laser Doppler. PO2 and PCO2 were measured at the dorsum of the foot. All 20 included patients completed the study. The two groups were comparable. In the PXF group there was a significant increase in RF, AEF, and in PO2 (p<0.05); PCO2 was decreased (p<0.05). There were also changes in the placebo group, significantly lower than those observed in the PXF group (p<0.05). In conclusion high-dose PXF treatments improved all microcirculatory parameters in subjects with short-range claudication even with a short period of treatment.
Authors:
L Incandela; M T De Sanctis; M R Cesarone; G Belcaro; A N Nicolaides; G Geroulakos; G Ramaswami
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Angiology     Volume:  53 Suppl 1     ISSN:  0003-3197     ISO Abbreviation:  Angiology     Publication Date:    2002 Jan-Feb
Date Detail:
Created Date:  2002-02-26     Completed Date:  2002-03-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0203706     Medline TA:  Angiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S27-30     Citation Subset:  IM    
Affiliation:
Department of Biomedical Sciences, Chieti University and San Valentino Vascular Screening Project, Pe, Italy.
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MeSH Terms
Descriptor/Qualifier:
Aged
Blood Pressure / drug effects,  physiology
Double-Blind Method
Exercise Test
Female
Humans
Intermittent Claudication / complications*,  drug therapy*,  physiopathology
Laser-Doppler Flowmetry
Male
Microcirculation / drug effects*,  physiopathology*
Middle Aged
Pain / drug therapy*,  etiology*,  physiopathology
Pentoxifylline / therapeutic use*
Rest / physiology*
Severity of Illness Index
Time Factors
Vasodilator Agents / therapeutic use*
Walking / physiology
Chemical
Reg. No./Substance:
0/Vasodilator Agents; 6493-05-6/Pentoxifylline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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