Document Detail

Short posterior ciliary artery, central retinal artery, and choroidal hemodynamics in brimonidine-treated primary open-angle glaucoma patients.
MedLine Citation:
PMID:  14644214     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Malfunction in peripapillary hemodynamics has been suggested to play a major part in the pathogenesis of primary open-angle glaucoma (POAG). The aim of this study was to determine whether topically applied brimonidine can influence blood hemodynamic characteristics associated with the perioptic short posterior ciliary arteries (SPCAs), central retinal artery (CRA), and choroidal vascular system in POAG patients. DESIGN: Randomized clinical trial. In this prospective, institutional, double-masked, vehicle-controlled, randomized clinical trial, the intraocular pressure (IOP) and vascular dynamics of the SPCAs, CRA, and choroidal vascular system were analyzed in both eyes of 17 POAG patients, before and after treatment with 0.2% brimonidine for 4 weeks. RESULTS: Mean IOP reduction was significant (18.7%) following treatment with brimonidine. However, no clear changes were recorded with respect to blood perfusion parameters (peak systolic velocity, end-diastolic velocity, pulsatility, and resistance indices) associated with the SPCAs and CRA or the choroidal ocular pulse amplitude. CONCLUSIONS: Topical treatment of brimonidine to POAG patients causes a significant reduction of IOP, but blood hemodynamic properties associated with the SPCAs, CRA, and choroidal vascular systems appeared unaffected. Topically applied brimonidine, therefore, appears not to constrict or dilate peripapillary blood vessels.
Karl-Georg Schmidt; Volker Klingmüller; Scott M Gouveia; Neville N Osborne; Lutz E Pillunat
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  American journal of ophthalmology     Volume:  136     ISSN:  0002-9394     ISO Abbreviation:  Am. J. Ophthalmol.     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2003-12-03     Completed Date:  2003-12-16     Revised Date:  2009-11-03    
Medline Journal Info:
Nlm Unique ID:  0370500     Medline TA:  Am J Ophthalmol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1038-48     Citation Subset:  AIM; IM    
Department of Ophthalmology, University of Dresden, Dresden, Germany.
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MeSH Terms
Administration, Topical
Adrenergic alpha-Agonists / therapeutic use*
Blood Flow Velocity
Choroid / blood supply*,  ultrasonography
Ciliary Arteries / physiology*,  ultrasonography
Double-Blind Method
Glaucoma, Open-Angle / drug therapy,  physiopathology*
Intraocular Pressure
Laser-Doppler Flowmetry
Middle Aged
Prospective Studies
Quinoxalines / therapeutic use*
Retinal Artery / physiology*,  ultrasonography
Reg. No./Substance:
0/Adrenergic alpha-Agonists; 0/Quinoxalines; 59803-98-4/brimonidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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