Document Detail

Short perioperative versus long-term adjuvant chemotherapy.
MedLine Citation:
PMID:  4035073     Owner:  NLM     Status:  MEDLINE    
A single course of cyclophosphamide IV 5 mg/kg daily for 6 days was given immediately after mastectomy to 507 patients (519 randomized controls). The relapse-free rates were significantly increased, and after 16 years the difference was 12%. In a parallel series the same adjuvant course was given 2-4 weeks after mastectomy to 52 patients (58 randomized controls). No effect of this delayed course was found. In a second study a short multidrug course was given to all patients immediately after mastectomy. One-half of the axillary node-positive cases were randomized to continue with IV CMF for 1 year. The preliminary observations show that the prolonged treatment improved the relapse-free rates significantly during the first few years. One year after mastectomy the difference was 10%; after 2 years, 9%; after 3 years, 11%; and after 4 years, 9%. The side-effects of the short course were negligible, but the side-effects of prolonged treatment were considerable and increased with increasing treatment duration. More trials are needed to find the optimum duration of adjuvant chemotherapy.
R Nissen-Meyer; H Host; K Kjellgren; B Mansson; T Norin
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer     Volume:  98     ISSN:  0080-0015     ISO Abbreviation:  Recent Results Cancer Res.     Publication Date:  1985  
Date Detail:
Created Date:  1985-10-10     Completed Date:  1985-10-10     Revised Date:  2008-02-13    
Medline Journal Info:
Nlm Unique ID:  0044671     Medline TA:  Recent Results Cancer Res     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  91-8     Citation Subset:  IM    
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MeSH Terms
Antineoplastic Agents / administration & dosage*
Antineoplastic Combined Chemotherapy Protocols / administration & dosage,  adverse effects
Breast Neoplasms / drug therapy*,  surgery
Combined Modality Therapy
Cyclophosphamide / administration & dosage,  adverse effects
Drug Administration Schedule
Random Allocation
Reg. No./Substance:
0/Antineoplastic Agents; 50-18-0/Cyclophosphamide

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