| Short- and long-term swimming exercise training increases myocardial insulin-like growth factor-I gene expression. | |
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MedLine Citation:
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PMID: 12550078 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES. We investigated the effect of short- and long-term swimming exercise, with or without insulin-like growth factor (IGF)-I administration, on the expression of myocardial IGFs and contractile proteins. METHODS: Sprague-Dawley male rats (n=36) were subjected to swimming exercise for 2 or 6 weeks. IGF-I (0.5mg/rat) was administered continuously for 1 week, using alzet osmotic pumps. Control groups remained sedentary. IGF-I, IGF-I receptor (IGF-IR), IGF-II, skeletal alpha-actin (sk-actin), and beta myosin heavy chain (beta MHC) mRNAs were measured using Northern blot analysis and RT-PCR. RESULTS: A significant 2-fold increase in myocardial IGF-I mRNA was found after 2 and 6 weeks of swimming in both IGF-I treated and untreated rats (p<0.001). IGF-IR mRNA was significantly (p<0.05) increased after 6 weeks of training only in the IGF-I treated animals. IGF-II mRNA remained unchanged at all time points. While beta MHC mRNA was significantly decreased (p=0.003) at 2 and 6 weeks, sk-actin mRNA remained unchanged. CONCLUSIONS: Short- and long-term swimming exercise training increase myocardial expression of IGF-I mRNA. Exogenous administration of IGF-I, during the first week of the exercise session, did not produce any effect on myocardial IGF-I but was associated with increased IGF-IR signal after the long-term exercise training. These data suggest a relationship between IGF-I expression and cardiac adaptation to exercise training. |
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Authors:
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M Scheinowitz; G Kessler-Icekson; S Freimann; R Zimmermann; W Schaper; E Golomb; N Savion; M Eldar |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society Volume: 13 ISSN: 1096-6374 ISO Abbreviation: Growth Horm. IGF Res. Publication Date: 2003 Feb |
Date Detail:
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Created Date: 2003-01-28 Completed Date: 2003-08-29 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 9814320 Medline TA: Growth Horm IGF Res Country: Scotland |
Other Details:
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Languages: eng Pagination: 19-25 Citation Subset: IM |
Affiliation:
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The Neufeld Cardiac Research Institute, Sheba Medical Center and Department of Biomedical Engineering, Tel-Aviv University, Tel-Hashomer 52621, Israel. mickeys@post.tau.ac.il |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Actins
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genetics,
metabolism Animals Blotting, Northern DNA Primers / chemistry Gene Expression Regulation* Heart Insulin-Like Growth Factor I / administration & dosage, genetics* Insulin-Like Growth Factor II / genetics, metabolism Male Muscle, Skeletal / metabolism Muscles / metabolism Myocardium / metabolism* Myosin Heavy Chains / genetics, metabolism Physical Conditioning, Animal* RNA, Messenger / metabolism Rats Rats, Sprague-Dawley Receptor, IGF Type 1 / genetics, metabolism Reverse Transcriptase Polymerase Chain Reaction Swimming* |
| Chemical | |
Reg. No./Substance:
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0/Actins; 0/DNA Primers; 0/Myosin Heavy Chains; 0/RNA, Messenger; 67763-96-6/Insulin-Like Growth Factor I; 67763-97-7/Insulin-Like Growth Factor II; EC 2.7.10.1/Receptor, IGF Type 1 |
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