Document Detail


Short- and long-term swimming exercise training increases myocardial insulin-like growth factor-I gene expression.
MedLine Citation:
PMID:  12550078     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES. We investigated the effect of short- and long-term swimming exercise, with or without insulin-like growth factor (IGF)-I administration, on the expression of myocardial IGFs and contractile proteins. METHODS: Sprague-Dawley male rats (n=36) were subjected to swimming exercise for 2 or 6 weeks. IGF-I (0.5mg/rat) was administered continuously for 1 week, using alzet osmotic pumps. Control groups remained sedentary. IGF-I, IGF-I receptor (IGF-IR), IGF-II, skeletal alpha-actin (sk-actin), and beta myosin heavy chain (beta MHC) mRNAs were measured using Northern blot analysis and RT-PCR. RESULTS: A significant 2-fold increase in myocardial IGF-I mRNA was found after 2 and 6 weeks of swimming in both IGF-I treated and untreated rats (p<0.001). IGF-IR mRNA was significantly (p<0.05) increased after 6 weeks of training only in the IGF-I treated animals. IGF-II mRNA remained unchanged at all time points. While beta MHC mRNA was significantly decreased (p=0.003) at 2 and 6 weeks, sk-actin mRNA remained unchanged. CONCLUSIONS: Short- and long-term swimming exercise training increase myocardial expression of IGF-I mRNA. Exogenous administration of IGF-I, during the first week of the exercise session, did not produce any effect on myocardial IGF-I but was associated with increased IGF-IR signal after the long-term exercise training. These data suggest a relationship between IGF-I expression and cardiac adaptation to exercise training.
Authors:
M Scheinowitz; G Kessler-Icekson; S Freimann; R Zimmermann; W Schaper; E Golomb; N Savion; M Eldar
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society     Volume:  13     ISSN:  1096-6374     ISO Abbreviation:  Growth Horm. IGF Res.     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-01-28     Completed Date:  2003-08-29     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9814320     Medline TA:  Growth Horm IGF Res     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  19-25     Citation Subset:  IM    
Affiliation:
The Neufeld Cardiac Research Institute, Sheba Medical Center and Department of Biomedical Engineering, Tel-Aviv University, Tel-Hashomer 52621, Israel. mickeys@post.tau.ac.il
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MeSH Terms
Descriptor/Qualifier:
Actins / genetics,  metabolism
Animals
Blotting, Northern
DNA Primers / chemistry
Gene Expression Regulation*
Heart
Insulin-Like Growth Factor I / administration & dosage,  genetics*
Insulin-Like Growth Factor II / genetics,  metabolism
Male
Muscle, Skeletal / metabolism
Muscles / metabolism
Myocardium / metabolism*
Myosin Heavy Chains / genetics,  metabolism
Physical Conditioning, Animal*
RNA, Messenger / metabolism
Rats
Rats, Sprague-Dawley
Receptor, IGF Type 1 / genetics,  metabolism
Reverse Transcriptase Polymerase Chain Reaction
Swimming*
Chemical
Reg. No./Substance:
0/Actins; 0/DNA Primers; 0/Myosin Heavy Chains; 0/RNA, Messenger; 67763-96-6/Insulin-Like Growth Factor I; 67763-97-7/Insulin-Like Growth Factor II; EC 2.7.10.1/Receptor, IGF Type 1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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