| Short- and long-term response to corticosteroid therapy in chronic beryllium disease. | |
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MedLine Citation:
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PMID: 18757698 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Chronic beryllium disease (CBD) is a granulomatous disorder that affects the lung after exposure to beryllium. The present study reports short- and long-term evolution of granulomatous and fibrotic components in eight patients with severe CBD receiving corticosteroid therapy. Eight patients with confirmed CBD were studied at baseline, after initial corticosteroid treatment (4-12 months), at relapse and at the final visit. Beryllium exposure, Glu(69) (HLA-DPB1 genes coding for glutamate at position beta69) polymorphism, symptoms, pulmonary function tests (PFT), serum angiotensin-converting enzyme (SACE) and high-resolution computed tomography (HRCT) quantification of pulmonary lesions were analysed. The CBD patients were observed for a median (range) of 69 (20-180) months. After stopping beryllium exposure, corticosteroids improved symptoms and PFT (vital capacity +26%, diffusing capacity of the lung for carbon monoxide +15%), and decreased SACE level and active lesion HRCT score. In total, 18 clinical relapses occurred after the treatment was tapered and these were associated with SACE and active lesion HRCT score impairment. At the final visit, corticosteroids had completely stabilised all parameters including both HRCT scores of active lesions and fibrotic lesions in six out of eight patients. Corticosteroids were beneficial in chronic beryllium disease. They were effective in suppressing granulomatosis lesions in all cases and in stopping the evolution to pulmonary fibrosis in six out of eight patients. |
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Authors:
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S Marchand-Adam; A El Khatib; F Guillon; M W Brauner; C Lamberto; V Lepage; J-M Naccache; D Valeyre |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology Volume: 32 ISSN: 1399-3003 ISO Abbreviation: Eur. Respir. J. Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2008-09-01 Completed Date: 2009-01-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8803460 Medline TA: Eur Respir J Country: Switzerland |
Other Details:
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Languages: eng Pagination: 687-93 Citation Subset: IM |
Affiliation:
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Université Paris 13, EA2363, Assistance Publique-Hôpital de Pol's, Service de Pneumologie, Bobigny, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Cortex Hormones
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therapeutic use* Adult Berylliosis / complications, drug therapy*, immunology Bronchoalveolar Lavage Fluid / cytology, immunology* Humans Longitudinal Studies Mass Screening* Middle Aged Pulmonary Fibrosis / etiology, prevention & control* Recovery of Function Respiratory Function Tests Retrospective Studies |
| Chemical | |
Reg. No./Substance:
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0/Adrenal Cortex Hormones |
| Comments/Corrections | |
Comment In:
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Eur Respir J. 2008 Sep;32(3):543-4
[PMID:
18757694
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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