Document Detail


Short- and long-term repeatability of fatty acid composition of human plasma phospholipids and cholesterol esters. The Atherosclerosis Risk in Communities (ARIC) Study Investigators.
MedLine Citation:
PMID:  7661119     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We examined short-term and long-term repeatability (reliability) of the fatty acid (FA) composition of plasma phospholipids and cholesterol esters (CEs). For short-term reliability, fasting blood samples of 34 subjects were collected three times, 2 wk apart, and in 24 subjects duplicate samples were collected during each visit. For long-term reliability, two fasting samples were collected in 50 subjects approximately 3 y apart. In both phospholipids and CEs, short-term and long-term reliability coefficients were > 0.65 for the major plasma FAs (16:0, 18:0, 18:2n-6, and 20:4n-6), with the exception of 18:1n-9, but were generally lower for FAs that compose < 1% of total FAs. Reliability tended to be better for CEs than for phospholipids. Method variability was small (< 5% of total variability for most FAs), indicating that biological and dietary variability contribute most to total variability. Plasma FA measurement warrants consideration as a biochemical marker of diet in epidemiologic studies.
Authors:
J Ma; A R Folsom; J H Eckfeldt; L Lewis; L E Chambless
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  62     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  1995 Sep 
Date Detail:
Created Date:  1995-10-03     Completed Date:  1995-10-03     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  572-8     Citation Subset:  AIM; IM    
Affiliation:
Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis 55454-1015, USA.
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MeSH Terms
Descriptor/Qualifier:
Cholesterol Esters / blood*
Fatty Acids / blood*,  classification
Female
Humans
Male
Middle Aged
Phospholipids / blood*
Reproducibility of Results
Time Factors
Grant Support
ID/Acronym/Agency:
N01-HC-55015/HC/NHLBI NIH HHS; N01-HC-55016/HC/NHLBI NIH HHS; R01-HL-40848/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Cholesterol Esters; 0/Fatty Acids; 0/Phospholipids

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