Document Detail


Short- and long-term prognostic value of the corrected QT interval in the non-ST-elevation acute coronary syndrome.
MedLine Citation:
PMID:  17254595     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND PURPOSE: Myocardial ischemia prolongs the QTc interval. Very little data exists about its prognostic implications in the non-ST-elevation acute coronary syndromes (NST-ACS). METHODS: This is and observational and prospective study in which we evaluated the prognostic implications of the QTc obtained at admission (AQTc) in the short- and long-term of the NST-ACS. The median of the follow-up was 17 months. RESULTS: AQTc correlated adequately with the incidence of adverse events in the short- and long-term (P < .001), with the best cut-off point in 450 milliseconds. Patients with AQTc > or =450 presented higher frequency of in-hospital death: 8.8% vs 1.2%; P = .001, and MACE (death, recurrent ischemia, or urgent coronary revascularization): 72% vs 25%; P < .001. In a Cox regression analysis, we found 3 independent predictors of cardiovascular death after discharge: AQTc > or =450 (14.7% vs 2.1%; P < .0001), age >65 years and left ventricular ejection fraction <40%. Coronary revascularization reduced the risk of posthospitalary cardiovascular death in AQTc > or =450 milliseconds (5% vs 24%; P < .0001) but had no significant effect in AQTc<450 milliseconds. CONCLUSION: These findings provide a new evidence supporting the prognostic value of the AQTc in predicting unfavorable events in the short- and long-term of the NST-ACS.
Authors:
Javier Jiménez-Candil; Ignacio Cruz González; José M González Matas; Carmen Albarrán; Pedro Pabón; José Luis Moríñigo; Claudio Ledesma; Francisco Martín; Maximiliano Diego; Cándido Martín-Luengo
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Publication Detail:
Type:  Journal Article     Date:  2007-01-24
Journal Detail:
Title:  Journal of electrocardiology     Volume:  40     ISSN:  1532-8430     ISO Abbreviation:  J Electrocardiol     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-03-12     Completed Date:  2007-04-03     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0153605     Medline TA:  J Electrocardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  180-7     Citation Subset:  IM    
Affiliation:
Department of Cardiology, University Hospital, Salamanca, Spain. jjimenezcandil@yahoo.es
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MeSH Terms
Descriptor/Qualifier:
Aged
Coronary Artery Disease / diagnosis*,  epidemiology*
Diagnosis, Computer-Assisted / methods,  statistics & numerical data
Electrocardiography / methods*,  statistics & numerical data
Female
Humans
Long QT Syndrome / diagnosis*,  epidemiology*
Male
Myocardial Ischemia / diagnosis*,  epidemiology*
Prognosis
Reproducibility of Results
Risk Assessment / methods
Risk Factors
Sensitivity and Specificity
Spain / epidemiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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