Document Detail

Short- and long-term mortality in patients with ST-elevation myocardial infarction treated with different therapeutic strategies. Results from WIelkopolska REgional 2002 Registry (WIRE Registry).
MedLine Citation:
PMID:  18344153     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Although primary coronary angioplasty seems to be the best treatment in acute myocardial infarction (MI), thrombolytic therapy still remains the most common reperfusion strategy particularly in smaller centers. Nowadays, different regional networks are developed to improve the treatment of patients with MI. AIM: To analyse the effects of different therapeutic strategies on 30-day and long-term mortality (median time 18.3 months) after ST-elevation MI (STEMI) in a population of 3 350 000 people from the Wielkopolska Region. METHODS: In 2002, 3780 patients with STEMI entered the registry. Complete data were available for 3564 (94.3%) patients. Depending on therapeutic strategies, patients were divided into five groups: the PCI group--direct percutaneous coronary angioplasty (PCI) in small cathlab, 'selected patients', n=381 (10.7%); the PA group--aged <70, treated with tissue plasminogen activator (rt-PA) up to 4 hours from the onset of chest pain, n=479 (13.4%); the IS group - invasive strategy in every patient, 24-hour duty, setting of unselected patients with STEMI, n=989 (27.7%); the SK group--patients receiving standard streptokinase treatment up to 12 hours from the onset of chest pain, n=584 (16.4%); the NR group--no reperfusion therapy, n=1131 (31.7%). RESULTS: The 30-day mortality rate in the groups above was: 3.15, 4.38, 4.54, 9.25, and 12.5% respectively (p <0.001). Long-term mortality rate was: 4.2, 9.4, 9.4, 14.4, and 18.50% respectively (p <0.001). The rate of urgent PCI in the PA group was 25% and in the SK group--11% (p <0.001). CONCLUSIONS: Treatment with rt-PA in patients under 70 years of age and up to 4 hours from pain onset may be an alternative to an invasive strategy. However, a quarter of those patients require urgent PCI. In long-term observation the mortality benefit can be clearly seen only in patients with early PCI.
Stefan Grajek; Maciej Lesiak; Aleksander Araszkiewicz; Małgorzata Pyda; Włodzimierz Skorupski; Marek Grygier; Przemysław Mitkowski; Marek Prech; Artur Baszko; Magdalena Janus; Piotr Breborowicz; Janusz Rzeźniczak; Janusz Tarchalski; Andrzej Główka; Andrzej Cieśliński
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Kardiologia polska     Volume:  66     ISSN:  0022-9032     ISO Abbreviation:  Kardiol Pol     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-03-17     Completed Date:  2008-08-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376352     Medline TA:  Kardiol Pol     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  154-63; discussion 164-5     Citation Subset:  IM    
1st Department of Cardiology, Pozan University of Medical Science, Poznan, Poland.
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MeSH Terms
Angioplasty, Transluminal, Percutaneous Coronary*
Fibrinolytic Agents / therapeutic use*
Middle Aged
Myocardial Infarction / diagnosis,  mortality*,  therapy*
Streptokinase / therapeutic use
Thrombolytic Therapy*
Tissue Plasminogen Activator / therapeutic use
Treatment Outcome
Reg. No./Substance:
0/Fibrinolytic Agents; EC 3.4.-/Streptokinase; EC Plasminogen Activator

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