Document Detail


Short and long term effects of juvenile stressor exposure on the expression of GABA(A) receptor subunits in rats.
MedLine Citation:
PMID:  22044189     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
During the juvenile period rodents are particularly sensitive to stressors. Aversive events encountered during this period may have enduring effects that are not evident among animals initially stressed as adults. Interestingly, experiencing stressor during juvenile period was found to elicit a biphasic behavioral pattern over the course of development. During the juvenile period, the expression of several GABA(A) receptor subunits are subject to elevated plasticity, rendering the GABAergic system sensitive to stressors. In the present investigation animals were exposed to a Juvenile variable stressor regiment (JUV-S) at 27-29 post natal days (PND): 27PND- acute swim stress (10 min), 28PND- elevated platform stress (3 sessions × 30 min each), and 29PND restraint (2h). One hour following the last exposure to stressor or in adulthood (60PND), anxiety-related behaviors were assessed in a 5 min elevated plus maze test. The western blotting technique was used to evaluate whether the juvenile stress induced behavioral pattern will be accompanied by respective changes in GABA(A) α1, α2 and α3 protein expression, in male rats. Our findings further established that juvenile stressor elicit hyper-reactivity when rats were tested as juveniles, whereas rats exhibited reduced activity and increased anxiety when tested as adults. Additionally, the effects of juvenile stressor on α1, α2 and α3 were more pronounced among juvenile stressed rats that were challenged as adults compared with rats that were only challenged as juveniles. Interestingly, the stressed induced modulation of the subunits was particularly evident in the amygdala, a brain region closely associated with anxiety. Thus, age and region- specific alterations of the α subunits may contribute to the age-specific behavioral alterations observed following juvenile stress exposure.
Authors:
Jacobson-Pick Shlomit; Richter-Levin Gal
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-11-1
Journal Detail:
Title:  Stress (Amsterdam, Netherlands)     Volume:  -     ISSN:  1607-8888     ISO Abbreviation:  -     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9617529     Medline TA:  Stress     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
The Department of Psychology, University of Haifa , Mount Carmel, 31905 Haifa , Israel.
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