Document Detail

Short- and long-term effects of endurance training in patients with mitochondrial myopathy.
MedLine Citation:
PMID:  19486129     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND PURPOSE: It is unknown whether prolonged training is a safe treatment to alleviate exercise intolerance in patients with mitochondrial DNA (mtDNA) mutations. METHODS: The effect of 3 and 12 months training and 3-12 months deconditioning was studied in four patients carrying different mtDNA mutations. RESULTS: Three-month moderate-intensity training increased oxidative capacity by 23%, which was sustained after 6-12 months of low-intensity training. Training and deconditioning did not induce adverse effects on clinical symptoms, muscle morphology and mtDNA mutation load in muscle. CONCLUSION: Long-term training effectively improves exercise capacity in patients with mitochondrial myopathy, and appears to be safe.
T D Jeppesen; M Dun??; M Schwartz; T Krag; J Rafiq; F Wibrand; J Vissing
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-05-27
Journal Detail:
Title:  European journal of neurology : the official journal of the European Federation of Neurological Societies     Volume:  16     ISSN:  1468-1331     ISO Abbreviation:  Eur. J. Neurol.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-11-25     Completed Date:  2010-02-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9506311     Medline TA:  Eur J Neurol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1336-9     Citation Subset:  IM    
Neuromuscular Research Unit, Department of Neurology, and the Copenhagen Muscle Research Centre, Copenhagen, Denmark.
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MeSH Terms
Exercise Therapy / methods*
Exercise Tolerance / physiology
Mitochondrial Myopathies / metabolism,  pathology,  rehabilitation*
Muscle, Skeletal / metabolism,  pathology

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