Document Detail


Short- and long-term changes in blood miRNA levels after nanogold injection in rats-potential biomarkers of nanoparticle exposure.
MedLine Citation:
PMID:  23030236     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Context: Increased use of engineered nanoparticles may result in exposure of workers and consumers, making them a health concern. Objective: To identify potential blood miRNA biomarkers after intravenous gold nanoparticle (AuNP) exposure. Materials and methods: miRNA microarray analysis was carried out on blood of rats at 1 week and 2 months after injection. Results: Many up- and downregulated miRNAs were detected. Of these, rno-miR-298 was confirmed to be increased at 1 week postinjection by reverse transcription-PCR (RT-PCR). Discussion and conclusion: Blood miRNAs could be useful as biomarkers for exposure to nanoparticles. miR-298 regulates β-amyloid (Aβ) precursor protein-converting enzyme-1 (BACE1) in Alzheimer's disease.
Authors:
Wee-Siong Chew; Kay-Wee Poh; Nikhat J Siddiqi; Abdullah S Alhomida; Liya E Yu; Wei-Yi Ong
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-3
Journal Detail:
Title:  Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals     Volume:  -     ISSN:  1366-5804     ISO Abbreviation:  Biomarkers     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9606000     Medline TA:  Biomarkers     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Neurobiology and Ageing Research Programme, National University of Singapore , Singapore 119260.
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