Document Detail

Short- and long-term black tea consumption reverses endothelial dysfunction in patients with coronary artery disease.
MedLine Citation:
PMID:  11447078     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Epidemiological studies suggest that tea consumption decreases cardiovascular risk, but the mechanisms of benefit remain undefined. Endothelial dysfunction has been associated with coronary artery disease and increased oxidative stress. Some antioxidants have been shown to reverse endothelial dysfunction, and tea contains antioxidant flavonoids. Methods and Results-- To test the hypothesis that tea consumption will reverse endothelial dysfunction, we randomized 66 patients with proven coronary artery disease to consume black tea and water in a crossover design. Short-term effects were examined 2 hours after consumption of 450 mL tea or water. Long-term effects were examined after consumption of 900 mL tea or water daily for 4 weeks. Vasomotor function of the brachial artery was examined at baseline and after each intervention with vascular ultrasound. Fifty patients completed the protocol and had technically suitable ultrasound measurements. Both short- and long-term tea consumption improved endothelium- dependent flow-mediated dilation of the brachial artery, whereas consumption of water had no effect (P<0.001 by repeated-measures ANOVA). Tea consumption had no effect on endothelium-independent nitroglycerin-induced dilation. An equivalent oral dose of caffeine (200 mg) had no short-term effect on flow-mediated dilation. Plasma flavonoids increased after short- and long-term tea consumption.
CONCLUSIONS: Short- and long-term black tea consumption reverses endothelial vasomotor dysfunction in patients with coronary artery disease. This finding may partly explain the association between tea intake and decreased cardiovascular disease events.
S J Duffy; J F Keaney; M Holbrook; N Gokce; P L Swerdloff; B Frei; J A Vita
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Circulation     Volume:  104     ISSN:  1524-4539     ISO Abbreviation:  Circulation     Publication Date:  2001 Jul 
Date Detail:
Created Date:  2001-07-11     Completed Date:  2001-08-09     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  United States    
Other Details:
Languages:  eng     Pagination:  151-6     Citation Subset:  AIM; IM    
Evans Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA, USA.
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MeSH Terms
Administration, Oral
Antioxidants / metabolism
Blood Glucose / drug effects
Brachial Artery / drug effects,  physiopathology,  ultrasonography
Caffeine / administration & dosage
Coronary Disease / blood,  physiopathology*
Cross-Over Studies
Endothelium, Vascular / drug effects*,  physiopathology*
Flavonoids / blood
Hemodynamics / drug effects
Lipids / blood
Middle Aged
Plant Extracts / administration & dosage
Tea / metabolism*
Vasodilation / drug effects
Vasodilator Agents / pharmacology
Vasomotor System / drug effects,  physiopathology
Grant Support
Reg. No./Substance:
0/Antioxidants; 0/Blood Glucose; 0/Flavonoids; 0/Lipids; 0/Plant Extracts; 0/Tea; 0/Vasodilator Agents; 58-08-2/Caffeine

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