Document Detail

Short- and long-term beta-carotene supplementation do not influence T cell-mediated immunity in healthy elderly persons.
MedLine Citation:
PMID:  9322568     Owner:  NLM     Status:  MEDLINE    
Supplementation of healthy elderly persons with beta-carotene has been considered a way to enhance immune responses. In study 1 the short-term effect of beta-carotene (90 mg/d for 3 wk) on immunity was assessed in a randomized, double-blind, placebo-controlled longitudinal comparison of healthy elderly women. In study 2 the long-term effect of beta-carotene (50 mg every other day for 10-12 y) on immunity was assessed in a randomized, double-blind, placebo-controlled longitudinal comparison of men enrolled in the Physicians' Health Study. Subjects from both studies taking active supplements had significantly greater plasma beta-carotene concentrations than did subjects taking placebo. The pre- to postintervention change in delayed-type hypersensitivity skin test responses between beta-carotene and placebo groups in the short-term study was not significantly different, nor was the response between treatment groups in the long-term study. There were no significant effects due to beta-carotene supplementation on in vitro lymphocyte proliferation, production of interleukin 2, or production of prostaglandin E2 as a result of short- or long-term beta-carotene supplementation. In addition, there were no differences in the profiles of lymphocyte subsets [total T cells (CD3+), T helper cells (CD4+), T cytotoxic-suppressor cells (CD8+), and B cells (CD19+)] due to short- or long-term beta-carotene supplementation, nor were there differences in percentages of CD16+ natural killer cells or activated lymphocytes (cells expressing interleukin 2 transferrin receptor) due to long-term beta-carotene supplementation. Consistent results from these two trials show that beta-carotene supplementation did not have an enhancing or suppressive effect on T cell-mediated immunity of healthy elderly.
M S Santos; L S Leka; J D Ribaya-Mercado; R M Russell; M Meydani; C H Hennekens; J M Gaziano; S N Meydani
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  66     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  1997 Oct 
Date Detail:
Created Date:  1997-10-31     Completed Date:  1997-10-31     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  917-24     Citation Subset:  AIM; IM    
Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA.
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MeSH Terms
Aged, 80 and over
Dinoprostone / analysis*,  secretion
Double-Blind Method
Follow-Up Studies
Hypersensitivity, Delayed / immunology
Immunity, Cellular / drug effects
Interleukin-2 / analysis*,  secretion
Leukocytes, Mononuclear / cytology,  drug effects*,  secretion
Longitudinal Studies
Lymphocyte Activation / drug effects*,  immunology
Lymphocyte Subsets / classification,  drug effects*,  immunology
Middle Aged
T-Lymphocytes / drug effects*,  immunology
Time Factors
beta Carotene / administration & dosage,  blood,  pharmacology*
Grant Support
Reg. No./Substance:
0/Capsules; 0/Interleukin-2; 363-24-6/Dinoprostone; 7235-40-7/beta Carotene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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