Document Detail


Short- and long-term adverse effects of cocaine abuse during pregnancy on the heart development.
MedLine Citation:
PMID:  19144667     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of cocaine on the developing fetus is a topic of considerable interest and debate. One of the potential effects of fetal cocaine exposure is damage to the developing heart. This review provides an overview of the current understanding of the short- and long-term effects of fetal cocaine exposure on the heart in both humans and animal models. Human studies are still preliminary but have suggested that fetal cocaine exposure impacts on the developing heart. Studies in animal models provide strong evidence for a programming effect resulting in detrimental long-term changes to the heart induced by fetal cocaine exposure. In the rat model, fetal cocaine results in apoptosis in the term heart, left ventricular remodeling and myocyte hypertrophy, as well as increased sensitivity to ischemia/reperfusion injury in the adult male offspring. The rat model has also shown evidence of epigenetic modifications in response to intrauterine cocaine. Increased DNA methylation of promoter regions leads to a long-term decrease in the expression of the cardioprotective gene, PKCepsilon. The current data shows fetal cocaine exposure has significant immediate and long-term cardiac consequences in animal models and while human studies are still incomplete they suggest this phenomenon may also be significant in humans exposed to cocaine during development.
Authors:
Kurt D Meyer; Lubo Zhang
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Therapeutic advances in cardiovascular disease     Volume:  3     ISSN:  1753-9447     ISO Abbreviation:  Ther Adv Cardiovasc Dis     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-01-15     Completed Date:  2009-03-05     Revised Date:  2014-09-12    
Medline Journal Info:
Nlm Unique ID:  101316343     Medline TA:  Ther Adv Cardiovasc Dis     Country:  England    
Other Details:
Languages:  eng     Pagination:  7-16     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Apoptosis
Cocaine-Related Disorders / complications*,  genetics,  physiopathology
DNA Methylation
Disease Models, Animal
Female
Fetal Heart / growth & development*,  pathology
Gene Expression Regulation, Developmental
Heart / growth & development*
Heart Diseases / etiology*,  genetics,  physiopathology
Humans
Male
Myocardium / pathology
Pregnancy
Pregnancy Complications / genetics,  physiopathology*
Prenatal Exposure Delayed Effects*
Rats
Risk Factors
Time Factors
Ventricular Function, Left
Grant Support
ID/Acronym/Agency:
HD31226/HD/NICHD NIH HHS; HL67745/HL/NHLBI NIH HHS; HL82779/HL/NHLBI NIH HHS; HL83966/HL/NHLBI NIH HHS; P01 HD031226/HD/NICHD NIH HHS; P01 HD031226-140006/HD/NICHD NIH HHS; R01 HL082779/HL/NHLBI NIH HHS; R01 HL082779-03/HL/NHLBI NIH HHS; R01 HL083966-02/HL/NHLBI NIH HHS
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