| Short and long QT syndromes: does QT length really matter? | |
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MedLine Citation:
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PMID: 20728018 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The short and long QT syndromes are inherited diseases associated with an increased risk for life-threatening arrhythmias. The first case of long QT syndrome (LQTS) was reported more than 150 years ago, and the study of this disease led to crucial advancement of our understanding of channelopathies and associated ventricular arrhythmias. Ten years ago, Gussak et al. reported four cases of idiopathic ventricular fibrillation in individuals from a family with a history of sudden cardiac death exhibited very short QT interval and labeled the disease: short QT syndrome (SQTS). Over this decade, the SQTS was found to be a rare inherited syndrome with the potential to provide novel insights into the main mechanisms of cardiac arrhythmogenicity. In this review, we discuss these mechanisms and provocatively question the role of the QT interval duration as a surrogate marker of increased risk for arrhythmia in both the LQTS and the SQTS. |
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Authors:
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Jean-Philippe Couderc; Coeli M Lopes |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
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Title: Journal of electrocardiology Volume: 43 ISSN: 1532-8430 ISO Abbreviation: J Electrocardiol Publication Date: 2010 Sep-Oct |
Date Detail:
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Created Date: 2010-08-23 Completed Date: 2011-01-11 Revised Date: 2011-09-13 |
Medline Journal Info:
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Nlm Unique ID: 0153605 Medline TA: J Electrocardiol Country: United States |
Other Details:
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Languages: eng Pagination: 396-9 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Center for Quantitative Electrocardiography and Cardiac Safety, Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA. jean-philippe.couderc@thew-project.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Arrhythmias, Cardiac
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complications,
genetics,
physiopathology* Channelopathies / complications, genetics, physiopathology* Death, Sudden, Cardiac / etiology Electrocardiography Humans Long QT Syndrome / complications, genetics, physiopathology Mutation Potassium Channels / genetics Risk Factors |
| Grant Support | |
ID/Acronym/Agency:
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5U24HL096556-03/HL/NHLBI NIH HHS; U24 HL096556-03/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Potassium Channels |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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