Document Detail


Short latency trigemino-sternocleidomastoid response in patients with migraine.
MedLine Citation:
PMID:  12796836     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To investigate the central trigeminal circuits in migraine patients. MATERIALS AND METHODS: Short latency responses can be recorded in sternocleidomastoid (SCM) muscles after stimulation of the trigeminal nerve (trigemino-cervical reflex). This brainstem reflex was investigated in 20 healthy subjects, in 20 patients suffering from migraine with aura (MWA) and in 20 patients suffering from migraine without aura (MWOA) during and between the attacks. RESULTS: The trigemino-cervical responses were bilaterally abnormal in 17 patients with MWA and 15 patients with MWOA during the headache attacks, in 11 patients with MWA and in 10 patients with MWOA during the interictal period. In the patients with normal trigemino-cervical responses during the pain-free phase the triptan was significantly more effective at relieving headache. CONCLUSIONS: Our findings further support and emphasise the role of the trigeminal system in the pathogenesis of migraine. The bilateral location of the abnormalities suggests a centrally located dysfunction. Therefore, the trigemino-cervical reflex is sensitive in disclosing a disturbed brainstem activity and may be an index of neuronal activity in the human brainstem; moreover their assessment may help as valuable prognostic tool for predicting the efficacy of triptans therapy.
Authors:
Raffaele Nardone; Frediano Tezzon
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of neurology     Volume:  250     ISSN:  0340-5354     ISO Abbreviation:  J. Neurol.     Publication Date:  2003 Jun 
Date Detail:
Created Date:  2003-06-10     Completed Date:  2003-08-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0423161     Medline TA:  J Neurol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  725-32     Citation Subset:  IM    
Affiliation:
Dept. of Neurology, F. Tappeiner Hospital, Via Rossini, 5, 39012 Merano, BZ, Italy. raffaele.nardone@asbmeran-o.it
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MeSH Terms
Descriptor/Qualifier:
Adult
Analysis of Variance
Brain Stem / physiopathology*
Case-Control Studies
Double-Blind Method
Electric Stimulation
Electromyography / methods
Epilepsy / physiopathology
Female
Functional Laterality
Humans
Male
Middle Aged
Migraine Disorders / physiopathology*
Neck Muscles / innervation*
Reaction Time / physiology*
Reflex / physiology*
Trigeminal Nerve / physiopathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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