Document Detail

Short-lasting systemic and regional benefits of early crystalloid infusion after intravenous inoculation of dogs with live Escherichia coli.
MedLine Citation:
PMID:  15933781     Owner:  NLM     Status:  MEDLINE    
We investigated the systemic and regional hemodynamic effects of early crystalloid infusion in an experimental model of septic shock induced by intravenous inoculation with live Escherichia coli. Anesthetized dogs received an intravenous infusion of 1.2 x 10(10) cfu/kg live E. coli in 30 min. After 30 min of observation, they were randomized to controls (no fluids; N = 7), or fluid resuscitation with lactated Ringer's solution, 16 ml/kg (N = 7) or 32 ml/kg (N = 7) over 30 min and followed for 120 min. Cardiac index, portal blood flow, mean arterial pressure, systemic and regional oxygen-derived variables, blood lactate, and gastric PCO2 were assessed. Rapid and progressive cardiovascular deterioration with reduction in cardiac output, mean arterial pressure and portal blood flow (approximately 50, approximately 25 and approximately 70%, respectively) was induced by the live bacteria challenge. Systemic and regional territories showed significant increases in oxygen extraction and in lactate levels. Significant increases in venous-arterial (approximately 9.6 mmHg), portal-arterial (approximately 12.1 mmHg) and gastric mucosal-arterial (approximately 18.4 mmHg) PCO2 gradients were also observed. Early fluid replacement, especially with 32 ml/kg volumes of crystalloids, promoted only partial and transient benefits such as increases of approximately 76% in cardiac index, of approximately 50% in portal vein blood flow and decreases in venous-arterial, portal-arterial, gastric mucosal-arterial PCO2 gradients (7.2 +/- 1.0, 7.2 +/- 1.3 and 9.7 +/- 2.5 mmHg, respectively). The fluid infusion promoted only modest and transient benefits, unable to restore the systemic and regional perfusional and metabolic changes in this hypodynamic septic shock model.
A G Garrido; L F Poli de Figueiredo; R J Cruz; E Silva; M Rocha E Silva
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-06-01
Journal Detail:
Title:  Brazilian journal of medical and biological research = Revista brasileira de pesquisas m?dicas e biol?gicas / Sociedade Brasileira de Biof?sica ... [et al.]     Volume:  38     ISSN:  0100-879X     ISO Abbreviation:  Braz. J. Med. Biol. Res.     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-06-03     Completed Date:  2006-01-23     Revised Date:  2010-03-22    
Medline Journal Info:
Nlm Unique ID:  8112917     Medline TA:  Braz J Med Biol Res     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  873-84     Citation Subset:  IM    
Servi?o de Fisiologia aplicada, InCor, Hospital das Cl?nicas, Universidade de S?o Paulo, SP, Brasil.
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MeSH Terms
Disease Models, Animal
Escherichia coli Infections / drug therapy*
Fluid Therapy / methods
Hemodynamics / drug effects*
Isotonic Solutions / administration & dosage*
Regional Blood Flow / drug effects
Shock, Septic / drug therapy*,  microbiology
Time Factors
Reg. No./Substance:
0/Isotonic Solutions; 0/crystalloid solutions

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