| Short ischemia causes endothelial dysfunction in porcine coronary vessels in an in vivo model. | |
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MedLine Citation:
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PMID: 11216759 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The aim of this study was to evaluate the effects of a short period of ischemia (10 mins) and a prolonged period of ischemia (60 mins) followed by reperfusion on coronary flow changes induced by acetylcholine (ACh), adenosine (ADO), and endothelin (ET). METHODS: The left anterior descending coronary artery in anesthetized pigs was occluded for 10 or 60 minutes followed by 120 minutes reperfusion. Thereafter, the flow changes in the left anterior descending coronary artery were studied after intracoronary infusion of ACh, ADO, and ET. RESULTS: Short-term ischemia (10 minutes) caused a decrease in vasodilatation, but not the vasoconstriction response to ACh. Prolonged ischemia (60 minutes) impaired ADO induced vasodilatation and aggravated ET evoked vasoconstriction. CONCLUSIONS: The present findings suggest that a short period of ischemia (10 minutes) causes disturbances of the endothelial regulation of coronary vascular tone and that this endothelial regulation is more sensitive, and precedes changes in vascular smooth muscle function after ischemia and reperfusion. |
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Authors:
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U Lockowandt; J Liska; A Franco-Cereceda |
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Publication Detail:
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Type: Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Annals of thoracic surgery Volume: 71 ISSN: 0003-4975 ISO Abbreviation: Ann. Thorac. Surg. Publication Date: 2001 Jan |
Date Detail:
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Created Date: 2001-02-16 Completed Date: 2001-03-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 15030100R Medline TA: Ann Thorac Surg Country: United States |
Other Details:
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Languages: eng Pagination: 265-9 Citation Subset: AIM; IM |
Affiliation:
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Department of Thoracic Surgery, Karolinska Hospital, Stockholm, Sweden. ulf.lockowandt@ks.se |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cardiopulmonary Bypass Coronary Vessels / physiopathology* Endothelium, Vascular / physiopathology* Female Ischemia / physiopathology* Male Muscle, Smooth, Vascular / physiopathology Myocardial Reperfusion Random Allocation Swine Time Factors Vasodilation |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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