Document Detail

Short interfering RNA and the central nervous system: development of nonviral delivery systems.
MedLine Citation:
PMID:  23289737     Owner:  NLM     Status:  Publisher    
The development of gene silencing therapies for neurological diseases has placed great importance on the delivery of short interfering RNA (siRNA) to the central nervous system (CNS). However, delivery of siRNA to neurons, glia and brain capillary endothelial cells (BCECs) has not been well established. This editorial describes different approaches that are being used to efficiently deliver siRNA to the CNS via intravenous, intracerebroventricular, or intranasal administration.
Kazutaka Nishina; Hidehiro Mizusawa; Takanori Yokota
Related Documents :
23976987 - Synapto-protective drugs evaluation in reconstructed neuronal network.
25046307 - Long-term depression at distinct glutamatergic synapses in the basal ganglia.
23176257 - The new kcnq2 activator 4-chlor-n-(6-chlor-pyridin-3-yl)-benzamid displays anticonvulsa...
23115177 - Thalamus-derived molecules promote survival and dendritic growth of developing cortical...
11070197 - Organization of retrosplenial cortical projections to the laterodorsal thalamic nucleus...
8544997 - Effects of upper cervical spinal cord stimulation on neurons in the lumbosacral enlarge...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-6
Journal Detail:
Title:  Expert opinion on drug delivery     Volume:  -     ISSN:  1744-7593     ISO Abbreviation:  Expert Opin Drug Deliv     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101228421     Medline TA:  Expert Opin Drug Deliv     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Tokyo Medical and Dental University, Graduate School, Department of Neurology and Neurological Science , 1-5-45, Yushima, Bunkyo-ku, Tokyo 113-8519 , Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The future of carbon dioxide for polymer processing in tissue engineering.
Next Document:  Attenuation of multiple Nef functions in HIV-1 elite controllers.