Document Detail


Short interfering RNA and the central nervous system: development of nonviral delivery systems.
MedLine Citation:
PMID:  23289737     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The development of gene silencing therapies for neurological diseases has placed great importance on the delivery of short interfering RNA (siRNA) to the central nervous system (CNS). However, delivery of siRNA to neurons, glia and brain capillary endothelial cells (BCECs) has not been well established. This editorial describes different approaches that are being used to efficiently deliver siRNA to the CNS via intravenous, intracerebroventricular, or intranasal administration.
Authors:
Kazutaka Nishina; Hidehiro Mizusawa; Takanori Yokota
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-6
Journal Detail:
Title:  Expert opinion on drug delivery     Volume:  -     ISSN:  1744-7593     ISO Abbreviation:  Expert Opin Drug Deliv     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101228421     Medline TA:  Expert Opin Drug Deliv     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Tokyo Medical and Dental University, Graduate School, Department of Neurology and Neurological Science , 1-5-45, Yushima, Bunkyo-ku, Tokyo 113-8519 , Japan.
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