| Short echo time proton spectroscopy of the brain in HIV infection/AIDS. | |
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MedLine Citation:
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PMID: 8544658 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Short echo time proton spectra have been acquired from the brains of 30 male homosexual Acquired Immunodeficiency Syndrome (AIDS) patients and 12 age-matched control subjects on a 1.5 T MR system. The acquisition protocol used stimulated acquisition voxel localisation with a voxel size of 8 ml and repeat, echo, and mixing times of 5000, 20, and 30 ms, respectively. A single 25.6-ms Gaussian water suppression pulse was used with 128 spectral acquisitions and the data were eddy current corrected using a water reference. Baseline-corrected spectra were nonlinearly least squares fitted to a model function consisting of Gaussian functions representing the major metabolites reported in short echo proton spectra. Results indicate that the N-acetyl/creatine (NA/Cr) ratio is significantly reduced by 20% in AIDS patients [NA/Cr = 1.91 (0.51)] compared to control subjects [NA/Cr = 2.37 (0.25)] at short echo times. |
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Authors:
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M Paley; I D Wilkinson; M A Hall-Craggs; W K Chong; R J Chinn; M J Harrison |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: Magnetic resonance imaging Volume: 13 ISSN: 0730-725X ISO Abbreviation: Magn Reson Imaging Publication Date: 1995 |
Date Detail:
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Created Date: 1996-02-13 Completed Date: 1996-02-13 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8214883 Medline TA: Magn Reson Imaging Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 871-5 Citation Subset: IM; X |
Affiliation:
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MRI Unit, Middlesex Hospital, University College London Hospitals, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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AIDS Dementia Complex
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metabolism* Adult Brain / metabolism* Humans Magnetic Resonance Spectroscopy / methods* Male |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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