| Short echo time in vivo prostate (1)H-MRSI. | |
| | |
MedLine Citation:
|
PMID: 22154684 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Visualization of short echo time (TE) metabolites in prostate magnetic resonance spectroscopic imaging is difficult due to lipid contamination and pulse timing constraints. In this work, we present a modified pulse sequence to permit short echo time (TE=40ms) acquisitions with reduced lipid contamination for the detection of short TE metabolites. The modified pulse sequence employs the conformal voxel MRS (CV-MRS) technique, which automatically optimizes the placement of spatial saturation planes to adapt the excitation volume to the shape of the prostate, thus reducing lipid contamination in prostate magnetic resonance spectroscopic imaging (MRSI). Metabolites were measured and assessed using a modified version of LCModel for analysis of in vivo prostate spectra. We demonstrate the feasibility of acquiring high quality spectra at short TEs, and show the measurement of short TE metabolites, myo-inositol, scyllo-inositol, taurine and glutamine/glutamate for both single and multi-voxel acquisitions. In single voxels experiments, the reduction in TE resulted in 57% improvement in the signal-to-noise ratio (SNR). Additional 3D MRSI experiments comparing short (TE=40 ms), and long (TE=130 ms) TE acquisitions revealed a 35% improvement in the number of adequately fitted metabolite peaks (775 voxels over all subjects). This resulted in a 42±24% relative improvement in the number of voxels with detectable citrate that were well-fitted using LCmodel. In this study, we demonstrate that high quality prostate spectra can be obtained by reducing the TE to 40 ms to detect short T2 metabolites, while maintaining positive signal intensity of the spin-coupled citrate multiplet and managing lipid suppression. |
| | |
Authors:
|
Niranjan Venugopal; Boyd McCurdy; Salem Al Mehairi; Aziz Alamri; Gurdarshan S Sandhu; Sri Sivalingam; Darrel Drachenberg; Lawrence Ryner |
Related Documents
:
|
18029994 - Positioning accuracy in a registration-free ct-based navigation system. 2052124 - Image-directed stereotactic drainage of the symptomatic cavum septi pellucidi et vergae. 3067114 - Magnetic resonance imaging stereotactic thalamotomy: report of a case with comparison t... 11356374 - Anesthetic protocol: propofol use in rhesus macaques (macaca mulatta) during magnetic r... 22434554 - Visualization of the normal appendix with mr enterography in children. 10069724 - Scintigraphic diagnosis of polysplenia in the adult. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-12-8 |
Journal Detail:
|
Title: Magnetic resonance imaging Volume: - ISSN: 1873-5894 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
|
Created Date: 2011-12-13 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8214883 Medline TA: Magn Reson Imaging Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
|
Department of Physics and Astronomy, University of Manitoba, Winnipeg, Manitoba, Canada; Department of Medical Physics, Cancer Care Manitoba, Winnipeg, Manitoba, Canada; National Research Council Institute for Biodiagnostics, Winnipeg, Manitoba, Canada. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Immunomodulatory Activities of Chitin Microparticles on Leishmania major-infected Murine Macrophages...
Next Document: Preclinical evaluation of [(11)C]NE40, a type 2 cannabinoid receptor PET tracer.