| Short echo time 1H MRSI of the human brain at 3T with adiabatic slice-selective refocusing pulses; reproducibility and variance in a dual center setting. | |
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MedLine Citation:
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PMID: 20027568 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To assess the reproducibility of (1)H-MR spectroscopic imaging (MRSI) of the human brain at 3T with volume selection by a double spin echo sequence for localization with adiabatic refocusing pulses (semi-LASER). MATERIALS AND METHODS: Twenty volunteers in two different institutions were measured twice with the same pulse sequence at an echo time of 30 msec. Magnetic resonance (MR) spectra were analyzed with LCModel with a simulated basis set including an experimentally acquired macromolecular signal profile. For specific regions in the brain mean metabolite levels, within and between subject variance, and the coefficient of variation (CoV) were calculated (for taurine, glutamate, total N-acetylaspartate, total creatine, total choline, myo-inositol + glycine, and glutamate + glutamine). RESULTS: Repeated measurements showed no significant differences with a paired t-test and a high reproducibility (CoV ranging from 3%-30% throughout the selected volume). Mean metabolite levels and CoV obtained in similar regions in the brain did not differ significantly between two contributing institutions. The major source of differences between different measurements was identified to be the between-subject variations in the volunteers. CONCLUSION: We conclude that semi-LASER (1)H-MRSI at 3T is an adequate method to obtain quantitative and reproducible measures of metabolite levels over large parts of the brain, applicable across multiple centers. |
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Authors:
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Jannie P Wijnen; Jack J A van Asten; Dennis W J Klomp; Torill E Sjobakk; Ingrid S Gribbestad; Tom W J Scheenen; Arend Heerschap |
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Publication Detail:
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Type: Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of magnetic resonance imaging : JMRI Volume: 31 ISSN: 1522-2586 ISO Abbreviation: J Magn Reson Imaging Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2009-12-28 Completed Date: 2010-03-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9105850 Medline TA: J Magn Reson Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 61-70 Citation Subset: IM |
Copyright Information:
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(c) 2009 Wiley-Liss, Inc. |
Affiliation:
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Department of Radiology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands. j.wijnen@rad.umcn.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Algorithms* Biological Markers / analysis* Brain / metabolism* Humans Magnetic Resonance Spectroscopy / methods* Male Protons / diagnostic use Reproducibility of Results Sensitivity and Specificity Tissue Distribution Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Protons |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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