Document Detail


Short communication: duplication in the 5'-flanking region of the beta-lactoglobulin gene is linked to the BLG A allele.
MedLine Citation:
PMID:  18024772     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
beta-Lactoglobulin (beta-LG) is the major whey protein in the milk of cows and other ruminants. It is well established that the predominant genetic variants beta-LG A and B are differentially expressed. Extensive investigation of the genetic variation in the promoter region of the BLG gene revealed the existence of specific haplotypes associated with the A and B variants. However, the genetic basis for the differentially expressed BLG A and B alleles is still elusive. In this study additional genetic variation further upstream in the 5'-flanking region of the BLG gene was identified, including 6 single nucleotide substitutions, a single nucleotide deletion, and a 7-bp duplication. Comparison of DNA sequences showed that the investigated 5'-flanking region is highly conserved between ruminants, and the duplication g.-1885_-1879dupCTCTCGC and the substitution g.-1888A>G are only found in the BLG A and D alleles in cattle. The cytosine at position g.-1957 and the thymines at positions g.-2008 and g.-2049 are only found in BLG B alleles of cattle. It is suggested that the described genetic variability contributes to the differential allelic expression of the BLG gene.
Authors:
M H Braunschweig
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of dairy science     Volume:  90     ISSN:  1525-3198     ISO Abbreviation:  J. Dairy Sci.     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-11-20     Completed Date:  2007-12-27     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  2985126R     Medline TA:  J Dairy Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  5780-3     Citation Subset:  IM    
Affiliation:
Institute of Genetics, University of Berne, CH-3001 Berne, Switzerland. martin.braunschweig@itz.unibe.ch
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
5' Flanking Region / genetics*
Alleles
Animals
Base Sequence
Cattle / genetics*,  physiology
Female
Gene Duplication*
Gene Expression
Genetic Variation*
Lactoglobulins / genetics*
Promoter Regions, Genetic
Chemical
Reg. No./Substance:
0/Lactoglobulins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Effects of breed, feeding system, and parity on udder health and milking characteristics.
Next Document:  Evaluation of the Dairy Comp 305 module "Cow Value" in two Ontario dairy herds.