Document Detail


Short chain fatty acids exchange across the gut and liver in humans measured at surgery.
MedLine Citation:
PMID:  19523724     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND & AIMS: Short chain fatty acids (SCFAs; acetate, propionate and butyrate) are important energy sources for colonocytes and are assumed to play a key role in gut health. Local effects of SCFAs have been investigated, but less is known about whole body metabolism of these SCFAs. The aim of the present study was to quantify the role of the gut and liver in interorgan exchange of SCFAs in humans in vivo. METHODS: Twenty-two patients undergoing major upper abdominal surgery were studied. Blood was sampled from a radial artery, the portal and a hepatic vein. Portal, splanchnic and arterial blood flow was measured using intra-operative Duplex ultrasonography. SCFAs were measured on a liquid chromatography system combined with mass spectrometry. RESULTS: SCFAs were released by the gut, 34.9 (9.1) micromol kg bodyweight(-1)h(-1). SCFAs uptake by the liver was significant for propionate and butyrate; -5.6 (1.3) and -3.8 (1.6) micromol kg bodyweight(-1)h(-1) (p=0.0002 and p=0.03) respectively and counterbalanced gut release. Liver uptake of acetate was not significant, -5.2 (6.6) micromol kg bodyweight(-1)h(-1) (p=0.434). Splanchnic (i.e., gut+liver) SCFAs release was significant for acetate and propionate, 17.3 (7.3) and 1.2 (0.4) micromol kg bodyweight(-1)h(-1) (p=0.027 and p=0.0038), respectively. Splanchnic release of butyrate was not significantly different from zero (1.9 (1.2) micromol kg bodyweight(-1)h(-1), p=0.129). BMI and previous colonic resection did not affect gut release of SCFAs. CONCLUSION: This is the first in vivo study on the role of the gut and liver in SCFAs exchange in humans in vivo. It is shown that intestinal SCFAs release by the gut is equalled by hepatic uptake.
Authors:
Johanne G Bloemen; Koen Venema; Marcel C van de Poll; Steven W Olde Damink; Wim A Buurman; Cornelis H Dejong
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-06-11
Journal Detail:
Title:  Clinical nutrition (Edinburgh, Scotland)     Volume:  28     ISSN:  1532-1983     ISO Abbreviation:  Clin Nutr     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-11-16     Completed Date:  2010-02-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8309603     Medline TA:  Clin Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  657-61     Citation Subset:  IM    
Affiliation:
Department of Surgery, Nutrition and Toxicology Research Institute Maastricht, Maastricht University Medical Centre, PO Box 5800, 6202 AZ, Maastricht, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Algorithms
Body Mass Index
Fatty Acids, Volatile / blood,  metabolism*
Female
Hepatic Veins
Humans
Intestinal Absorption
Intestines / blood supply*,  metabolism
Intraoperative Period
Liver / blood supply*,  metabolism
Male
Middle Aged
Portal Vein
Radial Artery
Regional Blood Flow
Spleen / blood supply
Ultrasonography, Doppler
Chemical
Reg. No./Substance:
0/Fatty Acids, Volatile

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