Document Detail


Short chain fatty acids are effective in short-term treatment of chronic radiation proctitis: randomized, double-blind, controlled trial.
MedLine Citation:
PMID:  10378604     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: Short chain fatty acids are the main energy source of colonocytes and their use may be impaired in chronic radiation proctitis. The aim of the present study was to evaluate the therapeutic effect of short chain fatty acid enemas in patients with chronic radiation proctitis. METHODS: A prospective, randomized, double-blind trial comparing short chain fatty acid enemas with placebo was conducted in 19 patients with chronic radiation proctitis. Short chain fatty acid enemas contained 60 mM sodium acetate, 30 mM sodium propionate, and 40 mM sodium butyrate. The treatment period lasted five weeks and patients were followed up for six months. RESULTS: On admission, both groups were similar regarding all parameters evaluated. After five weeks short chain fatty acid-treated patients showed a significant decrease in the number of days with rectal bleeding from the previous week (4.4+/-1.8 to 1.4+/-2.2; P = 0.001) and an improvement of endoscopic score (4.8+/-1.4 to 2.2+/-1.2; P = 0.001). Hemoglobin values were also significantly higher in short chain fatty acid-treated patients (13.1+/-0.9 g/dl vs. 10.7+/-2.1 g/dl; P = 0.02). Mucosal DNA and protein concentrations decreased in both groups but significantly so only in placebo-treated patients (P = 0.05). Changes in histologic parameters were not significant in either group. Although short chain fatty acid-treated patients did not get worse in the next six months, placebo-treated ones gradually improved, and at the end of six months, differences between the two groups were no longer observed. CONCLUSIONS: Short chain fatty acid enemas can accelerate the process of healing in chronic radiation proctitis, but treatment has to be continuous if a complete and sustained clinical, endoscopic, and histologic response is to be obtained.
Authors:
A Pinto; P Fidalgo; M Cravo; J Midões; P Chaves; J Rosa; M dos Anjos Brito; C N Leitão
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Diseases of the colon and rectum     Volume:  42     ISSN:  0012-3706     ISO Abbreviation:  Dis. Colon Rectum     Publication Date:  1999 Jun 
Date Detail:
Created Date:  1999-07-08     Completed Date:  1999-07-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372764     Medline TA:  Dis Colon Rectum     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  788-95; discussion 795-6     Citation Subset:  IM    
Affiliation:
Serviço de Gastrenterologia, Lisboa, Portugal.
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MeSH Terms
Descriptor/Qualifier:
Chronic Disease
Double-Blind Method
Enema
Fatty Acids, Volatile / administration & dosage,  therapeutic use*
Female
Humans
Male
Middle Aged
Proctitis / drug therapy*,  etiology
Prospective Studies
Radiation Injuries / drug therapy*
Time Factors
Chemical
Reg. No./Substance:
0/Fatty Acids, Volatile

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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