Document Detail

Short-term micronutrient supplementation reduces the duration of pneumonia and diarrheal episodes in HIV-infected children.
MedLine Citation:
PMID:  20335632     Owner:  NLM     Status:  MEDLINE    
The duration of pneumonia and of diarrhea is reported to be longer in HIV-infected than in uninfected children. We assessed the effect of a multi-micronutrient supplement on the duration of hospitalization in HIV-infected children. In a double-blind, randomized trial, HIV-infected children (4-24 mo) who were hospitalized with diarrhea or pneumonia were enrolled (n = 118) and given a daily dose of a multi-micronutrient supplement (containing vitamins A, B complex, C, D, E, and folic acid, as well as copper, iron, and zinc at levels based on recommended daily allowances) or a placebo until discharge from the hospital. Children's weights and heights were measured after enrollment and micronutrient concentrations were measured before discharge. On recovery from diarrhea or pneumonia, the children were discharged and the duration of hospitalization was noted. Anthropometric indices and micronutrient concentrations did not differ between children who received supplements and those who received placebos. Overall, the duration of hospitalization was shorter (P < 0.05) among children who were receiving supplements (7.3 +/- 3.9 d) (mean +/- SD) than in children who were receiving placebos (9.0 +/- 4.9); this was independent of admission diagnosis. In children admitted with diarrhea, the duration of hospitalization was 1.6 d (19%) shorter among children receiving supplements than in those receiving placebos, and hospitalization for pneumonia was 1.9 d (20%) shorter among children receiving supplements. Short-term multi-micronutrient supplementation significantly reduced the duration of pneumonia or diarrhea in HIV-infected children who were not yet receiving antiretroviral therapy and who remained alive during hospitalization.
Siyazi Mda; Joop M A van Raaij; Fran?ois P R de Villiers; Una E MacIntyre; Frans J Kok
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2010-03-24
Journal Detail:
Title:  The Journal of nutrition     Volume:  140     ISSN:  1541-6100     ISO Abbreviation:  J. Nutr.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-21     Completed Date:  2010-05-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  969-74     Citation Subset:  IM    
Department of Paediatrics and Child Health, and; 5Institute for Human Nutrition, University of Limpopo, Medunsa Campus, Pretoria 0204, South Africa.
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MeSH Terms
Child, Preschool
Diarrhea / complications,  drug therapy*
Dietary Supplements*
Double-Blind Method
HIV Infections / complications,  drug therapy*
Length of Stay
Pneumonia / complications,  drug therapy*
Trace Elements / therapeutic use*
Treatment Outcome
Vitamins / therapeutic use*
Reg. No./Substance:
0/Trace Elements; 0/Vitamins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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