Document Detail

Short-term exposure to exogenous lipids in premature infants and long-term changes in aortic and cardiac function.
MedLine Citation:
PMID:  21817105     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Intravenous lipid use is associated with an acute hyperlipidemia, but long-term consequences have not been studied. We investigated whether elevated lipids in humans during the critical period of preterm neonatal life have a long-term impact on aortic and myocardial function relevant to adult disease.
METHODS AND RESULTS: We followed up 102 subjects born prematurely and now aged 23 to 28 years. Eighteen received intravenous lipids as neonates and were matched to controls with equivalent perinatal characteristics. Global and regional aortic stiffness and left ventricular function were assessed by cardiovascular magnetic resonance. Those who received intravenous lipids had greater aortic stiffness in early adulthood (P=0.0002), with greater stiffness in the abdominal aorta (P=0.012). The relationship was graded according to the elevation in neonatal cholesterol induced by intravenous lipids (P<0.0001) but not other metabolic parameters altered by the infusion. Peak systolic circumferential strain was also reduced in the lipid group (P=0.006), which, again, was proportional to neonatal cholesterol level (P<0.01).
CONCLUSIONS: Aortic and myocardial function in young adulthood is associated with intralipid exposure during neonatal life for preterm infants, in a graded manner related to the rise in cholesterol. Circulating cholesterol during critical developmental periods may have long-term impacts on the human cardiovascular system.
Adam J Lewandowski; Merzaka Lazdam; Esther Davis; Ilias Kylintireas; Jonathan Diesch; Jane Francis; Stefan Neubauer; Atul Singhal; Alan Lucas; Brenda Kelly; Paul Leeson
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2011-08-04
Journal Detail:
Title:  Arteriosclerosis, thrombosis, and vascular biology     Volume:  31     ISSN:  1524-4636     ISO Abbreviation:  Arterioscler. Thromb. Vasc. Biol.     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-08-18     Completed Date:  2011-10-13     Revised Date:  2014-06-10    
Medline Journal Info:
Nlm Unique ID:  9505803     Medline TA:  Arterioscler Thromb Vasc Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2125-35     Citation Subset:  IM    
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MeSH Terms
Aorta / physiology*
Cholesterol / blood
Emulsions / pharmacology
Heart / physiology*
Hyperlipoproteinemia Type II / etiology
Infant, Newborn
Infant, Premature
Phospholipids / pharmacology*
Pulsatile Flow
Soybean Oil / pharmacology*
Young Adult
Grant Support
090532//Wellcome Trust; FS/06/024//British Heart Foundation; FS/11/65/28865//British Heart Foundation; G0700349//Medical Research Council
Reg. No./Substance:
0/Emulsions; 0/Phospholipids; 0/soybean oil, phospholipid emulsion; 8001-22-7/Soybean Oil; 97C5T2UQ7J/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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