Document Detail

A short synthesis of the triazolopyrimidine antibiotic essramycin.
MedLine Citation:
PMID:  20836523     Owner:  NLM     Status:  MEDLINE    
A short synthesis of the 1,2,4-triazolo[1,5-a]pyrimidine antibiotic essramycin is described involving condensation of aminoguanidine with ethyl benzoylacetate to give an amino-1,2,4-triazole, followed by condensation with ethyl acetoacetate to form the pyrimidone ring.
Ugo Battaglia; Christopher J Moody
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Publication Detail:
Type:  Journal Article     Date:  2010-09-13
Journal Detail:
Title:  Journal of natural products     Volume:  73     ISSN:  1520-6025     ISO Abbreviation:  J. Nat. Prod.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-29     Completed Date:  2010-12-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7906882     Medline TA:  J Nat Prod     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1938-9     Citation Subset:  IM    
School of Chemistry, University of Nottingham, University Park, Nottingham, NG7 2RD, United Kingdom.
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MeSH Terms
Anti-Bacterial Agents / chemical synthesis*,  chemistry,  pharmacology
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Pyrimidinones / chemical synthesis*,  chemistry,  pharmacology
Streptomyces / chemistry
Triazoles / chemical synthesis*,  chemistry,  pharmacology
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Pyrimidinones; 0/Triazoles; 0/essramycin; 288-88-0/1,2,4-triazole

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