| Short Synthesis of Ethyl 3-(3-aminophenyl)propanoate. | |
| | |
MedLine Citation:
|
PMID: 21989585 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
A short and effective synthesis of ethyl 3-(3-aminophenyl)propanoate is presented, employing a tandem Knoevenagel condensation/alkylidene reduction of 3-nitrobenzaldehyde with Meldrum's acid in TEAF (triethylammonium formate) followed by reduction of the intermediate 3-(3-nitrophenyl)propanoic acid by stannous chloride in ethanol. The use of stannous chloride as the reducing agent in ethanol enabled the simultaneous esterification of the carboxylic acid. Thus, stannous chloride was acting simultaneously as a Lewis acid, which activates the carboxylic acid towards a nucleophilic attack by ethanol. |
| | |
Authors:
|
Ulrike Nagel; Gregor Radau; Andreas Link |
Related Documents
:
|
11164305 - Changes in glycogen and trehalose content of streptomyces brasiliensis hyphae during gr... 14594845 - Starvation survival response of mycobacterium tuberculosis. 1102535 - Polypeptide nature of growth requirement in yeast extract for thermoplasma acidophilum. 17970215 - Effect of amino acids and antibodies against nerve growth factor receptors on the devel... 11516225 - Hepatothermic therapy of obesity: rationale and an inventory of resources. 19879245 - Lipids modulate h(2)s/hs(-) induced no release from s-nitrosoglutathione. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-10-12 |
Journal Detail:
|
Title: Archiv der Pharmazie Volume: - ISSN: 1521-4184 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
|
Created Date: 2011-10-12 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0330167 Medline TA: Arch Pharm (Weinheim) Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Affiliation:
|
Institute of Pharmacy, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Orofacial Clefts.
Next Document: Prevalence and predictors of interval colorectal cancers in Medicare beneficiaries.