| Short QT syndrome. | |
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MedLine Citation:
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PMID: 16255754 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Short QT syndrome (SQTS) is an inheritable primary electrical disease of the heart, discovered in 1999. It is characterized by an abnormally short QT interval (<300 ms) and a propensity to atrial fibrillation and sudden cardiac death (SCD). Like in the case of long QT syndrome there is more than one genetic mutation that can lead to a short QT interval in the ECG and so far two have been identified. Shortening of the effective refractory period combined with increased dispersion of repolarization is the likely substrate for reentry and life threatening tachyarrhythmias. Only 22 people have been classified as having SQTS: 15 from the actual measurement of a short QT interval in their ECG and 7 by history, all having died from SCD. It is very likely that several cases, especially among children, have been overlooked, since the shortness of the QT interval only becomes apparent at heart rates <80 beats/min. The best form of treatment is still not known, but prevention of atrial fibrillation has been accomplished by propafenone, and an implantable cardioverter defibrillator is recommended for prevention of SCD. |
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Authors:
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Preben Bjerregaard; Ihor Gussak |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc Volume: 10 ISSN: 1082-720X ISO Abbreviation: Ann Noninvasive Electrocardiol Publication Date: 2005 Oct |
Date Detail:
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Created Date: 2005-10-31 Completed Date: 2006-01-20 Revised Date: 2008-03-10 |
Medline Journal Info:
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Nlm Unique ID: 9607443 Medline TA: Ann Noninvasive Electrocardiol Country: United States |
Other Details:
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Languages: eng Pagination: 436-40 Citation Subset: IM |
Affiliation:
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Saint Louis University Hospital, 12th Floor, 2635 Vista Avenue at Grand, St. Louis, MO 63110, USA. bjerregp@slu.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Arrhythmia Agents
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therapeutic use* Arrhythmias, Cardiac / diagnosis*, mortality, therapy* Clinical Trials as Topic Electrocardiography / methods* Female Humans Male Physician's Practice Patterns Practice Guidelines as Topic Syndrome |
| Chemical | |
Reg. No./Substance:
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0/Anti-Arrhythmia Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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