Document Detail

The short QT syndrome: proposed diagnostic criteria.
MedLine Citation:
PMID:  21310316     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: We aimed to develop diagnostic criteria for the short QT syndrome (SQTS) to facilitate clinical evaluation of suspected cases.
BACKGROUND: The SQTS is a cardiac channelopathy associated with atrial fibrillation and sudden cardiac death. Ten years after its original description, a consensus regarding an appropriate QT interval cutoff and specific diagnostic criteria have yet to be established.
METHODS: The MEDLINE database was searched for all reported cases of SQTS in the English language, and all relevant data were extracted. The distribution of QT intervals and electrocardiographic (ECG) features in affected cases were analyzed and compared to data derived from ECG analysis from general population studies.
RESULTS: A total of 61 reported cases of SQTS were identified. Index events, including sudden cardiac death, aborted cardiac arrest, syncope, and/or atrial fibrillation occurred in 35 of 61 (57.4%) cases. The cohort was predominantly male (75.4%) and had a mean QT(c) value of 306.7 ms with values ranging from 248 to 381 ms in symptomatic cases. In reference to the ECG characteristics of the general population, and in consideration of clinical presentation, family history, and genetic findings, a highly sensitive diagnostic scoring system was developed.
CONCLUSIONS: Based on a comprehensive review of 61 reported cases of the SQTS, formal diagnostic criteria have been proposed that will facilitate diagnostic evaluation in suspected cases of SQTS. Diagnostic criteria may lead to a greater recognition of this condition and provoke screening of at-risk family members.
Michael H Gollob; Calum J Redpath; Jason D Roberts
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the American College of Cardiology     Volume:  57     ISSN:  1558-3597     ISO Abbreviation:  J. Am. Coll. Cardiol.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-02-11     Completed Date:  2011-03-24     Revised Date:  2011-09-07    
Medline Journal Info:
Nlm Unique ID:  8301365     Medline TA:  J Am Coll Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  802-12     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2011 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.
Inherited Arrhythmia Clinic and Arrhythmia Research Laboratory, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.
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MeSH Terms
Arrhythmias, Cardiac / diagnosis*,  genetics,  physiopathology
Comment In:
J Am Coll Cardiol. 2011 Jul 26;58(5):549-50; author reply 550-1   [PMID:  21777756 ]

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